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Childhood Metabolic Biomarkers Are Associated with Performance on Cognitive Tasks in Young Children.
Shapiro, Allison L B; Wilkening, Greta; Aalborg, Jenny; Ringham, Brandy M; Glueck, Deborah H; Tregellas, Jason R; Dabelea, Dana.
Afiliação
  • Shapiro ALB; Department of Psychiatry, School of Medicine, University of Colorado at Anschutz, Aurora, CO. Electronic address: allison.shapiro@ucdenver.edu.
  • Wilkening G; Neuropsychology, Children's Hospital Colorado, Anschutz Medical Campus, Aurora, CO.
  • Aalborg J; Department of Epidemiology, Colorado School of Public Health, University of Colorado at Anschutz, Aurora, CO; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado at Anschutz, Aurora, CO.
  • Ringham BM; Department of Epidemiology, Colorado School of Public Health, University of Colorado at Anschutz, Aurora, CO; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado at Anschutz, Aurora, CO.
  • Glueck DH; Department of Epidemiology, Colorado School of Public Health, University of Colorado at Anschutz, Aurora, CO; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado at Anschutz, Aurora, CO.
  • Tregellas JR; Department of Psychiatry, School of Medicine, University of Colorado at Anschutz, Aurora, CO; Research Service, Denver Veteran's Administration Medical Center, Denver, CO.
  • Dabelea D; Department of Epidemiology, Colorado School of Public Health, University of Colorado at Anschutz, Aurora, CO; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado at Anschutz, Aurora, CO.
J Pediatr ; 211: 92-97, 2019 08.
Article em En | MEDLINE | ID: mdl-31060808
OBJECTIVE: To evaluate the hypothesis that metabolic measures (fasting glucose, insulin, and Homeostatic Model of Assessment for Insulin Resistance [HOMA-IR] levels) are inversely associated with performance on cognitive tasks using data from young (4- to 6-year-old), typically developing, healthy children. STUDY DESIGN: Data were obtained from children participating in the Healthy Start study, a pre-birth cohort in Colorado. HOMA-IR, glucose, and insulin values were centered and scaled using the study sample means and SD. Thus, they are reported in number of SD units from the mean. Fully corrected T scores for inhibitory control (Flanker task), cognitive flexibility (Dimensional Change Card Sort test), and receptive language (Picture Vocabulary test) were obtained via the National Institutes of Health Toolbox cognition battery. RESULTS: Children included in this analysis (n = 137) were 4.6 years old, on average. Per 1-SD unit, fasting glucose (B = -2.0, 95% CI -3.5, -0.5), insulin (B = -1.7, 95% CI -3.0, -0.4), and HOMA-IR values (B = -1.8, 95% CI -3.1, -0.5) were each significantly and inversely associated with inhibitory control (P < .05 for all, respectively). Fasting glucose levels were also inversely associated with cognitive flexibility (B = -2.0, 95% CI -3.7, -0.2, P = .03). CONCLUSIONS: Our data suggest that metabolic health may impact fluid cognitive function in healthy, young children.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Biomarcadores / Cognição / Insulina Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Biomarcadores / Cognição / Insulina Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos