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Survival outcomes in patients aged 75 years and over with peritoneal colorectal carcinomatosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC): multicenter study of the Spanish Group of Peritoneal Cancer Surgery (GECOP).
Cascales-Campos, P A; López-López, V; Torres-Melero, J; Arjona, A; Muñoz-Casares, F C; Barrios, P; Morales, R; Pereira, F; Bretcha-Boix, P; González-Bayón, L; González-Moreno, S; Gil, J.
Afiliação
  • Cascales-Campos PA; Hospital Clínico, Universitario Virgen De La Arrixaca, Carretera Madrid-Cartagena S/N, El Palmar, CP: 30120, Murcia, Spain. cascalescirugia@gmail.com.
  • López-López V; IMIB-Arrixaca, Murcia, Spain. cascalescirugia@gmail.com.
  • Torres-Melero J; Hospital Clínico, Universitario Virgen De La Arrixaca, Carretera Madrid-Cartagena S/N, El Palmar, CP: 30120, Murcia, Spain.
  • Arjona A; IMIB-Arrixaca, Murcia, Spain.
  • Muñoz-Casares FC; Hospital Universitario De Torrecárdenas, Almería, Andalucia, Spain.
  • Barrios P; Hospital Universitario Reina Sofía, Córdoba, Andalucia, Spain.
  • Morales R; Hospital Universitario Reina Sofía, Córdoba, Andalucia, Spain.
  • Pereira F; Hospital Universtiario Virgen del Rocio, Sevilla, Spain.
  • Bretcha-Boix P; Hospital De Sant Joan De Espi Moises Broggi, Sant Joan De Espi, Cataluña, Spain.
  • González-Bayón L; Hospital Universitario Son Espases, Palma de Mayorca, Islas Baleares, Spain.
  • González-Moreno S; Hospital Universitario De Fuenlabrada, Madrid, Spain.
  • Gil J; Hospital Quirón de Torrevieja, Alicante, Comunidad Valenciana, Spain.
Clin Transl Oncol ; 22(1): 130-136, 2020 Jan.
Article em En | MEDLINE | ID: mdl-31049819
BACKGROUND: The attitude toward cytoreductive surgery with HIPEC in peritoneal carcinomatosis from colorectal cancer is unclear. The aim of this study is to report the perioperative outcomes after cytoreductive surgery with HIPEC in patients ≥ 75 years. METHODS: This retrospective multicenter study collected the data the Spanish Group of Peritoneal Cancer Surgery. Thirty-six patients with peritoneal carcinomatosis from colorectal cancer met the selection criteria for the study. Morbidity, mortality, disease-free and overall survival were analyzed. RESULTS: Morbidity (grade III-IV) was 17% and 2 patients died of complications related to the procedure (5.4%). Median disease-free survival (DFS) was 16 months. DFS at 1 and 3 years was 81% and 42%, respectively. Overall survival at 1 and 3 years was 96% and 75%. In the univariate analysis, preoperative comorbidities (p = 0.01), liver metastases (p = 0.02), blood transfusion (p = 0.001) and postoperative complications (p = 0.001); and in the multivariate analysis, perioperative blood transfusion (OR 2.56, 95% CI 1.95-6.24, p = 0.03) and postoperative complications (OR 3.25, 95% CI 2.35-7.56, p = 0.02) were associated with a lower overall survival. CONCLUSIONS: Age is not an absolute contraindication to perform cytoreduction surgery with HIPEC in highly selected elderly patients with colorectal peritoneal carcinomatosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Peritoneais / Quimioterapia do Câncer por Perfusão Regional / Neoplasias Colorretais / Protocolos de Quimioterapia Combinada Antineoplásica / Procedimentos Cirúrgicos de Citorredução / Hipertermia Induzida Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Peritoneais / Quimioterapia do Câncer por Perfusão Regional / Neoplasias Colorretais / Protocolos de Quimioterapia Combinada Antineoplásica / Procedimentos Cirúrgicos de Citorredução / Hipertermia Induzida Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália