Parental perinatal exposure to bisphenol A reduces the threshold to disrupt blastocyst implantation via decreasing talin, occudin and E-cadherin levels.
Reprod Toxicol
; 86: 86-97, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-31028817
The aim was to evaluate the effect of perinatal BPA exposure of one or both parents on the implantation index and expression of talin, occludin and E-cadherin in the uterine epithelial cells (UEC) of the offspring. Pregnant Wistar dams (F0) received BPA or vehicle from gestational day (GD) 6 to lactation day 21. F1 animals were mated forming four groups: Control dam-Control sire (Câ-Câ), BPA dam -Control sire (Bâ-Câ), Control dam -BPA sire (Câ-Bâ), BPA dam -BPA sire (Bâ-Bâ). F1 dams were sacrificed at GD 6. Significantly decreased number of implantation sites was observed in the Bâ-Bâ group as compared to the Câ-Câ group, which correlated with decreased talin apical/basal expression ratio, occludin apical expression, and E-cadherin apical/lateral expression ratio in the UEC. Furthermore, decreased E-cadherin expression in the blastocyst was observed. Our data suggest that reduced protein expressions in F1 BPA offspring could result from decreased progesterone serum levels.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Implantação do Embrião
/
Fenóis
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Compostos Benzidrílicos
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Caderinas
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Talina
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Ocludina
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Troca Materno-Fetal
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Reprod Toxicol
Assunto da revista:
EMBRIOLOGIA
/
MEDICINA REPRODUTIVA
/
TOXICOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Estados Unidos