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Antidepressive effects of a chemically characterized maqui berry extract (Aristotelia chilensis (molina) stuntz) in a mouse model of Post-stroke depression.
Di Lorenzo, Arianna; Sobolev, Anatoly P; Nabavi, Seyed Fazel; Sureda, Antoni; Moghaddam, Akbar Hajizadeh; Khanjani, Sedigheh; Di Giovanni, Carmen; Xiao, Jianbo; Shirooie, Samira; Tsetegho Sokeng, Arold Jorel; Baldi, Alessandra; Mannina, Luisa; Nabavi, Seyed Mohammad; Daglia, Maria.
Afiliação
  • Di Lorenzo A; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, Pavia 27100, Italy. Electronic address: arianna.dilorenzo1@gmail.com.
  • Sobolev AP; Istituto di Metodologie Chimiche, Laboratorio di Risonanza Magnetica "Annalaura Segre", CNR, 00015, Monterotondo (Rome), Italy. Electronic address: anatoly.sobolev@cnr.it.
  • Nabavi SF; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box, 19395-5487, Tehran, 19395-5487, Iran. Electronic address: nabavisf@gmail.com.
  • Sureda A; Grup de Nutrició Comunitària I Estrès Oxidatiu and CIBEROBN (Physiopathology of Obesity and Nutrition), Universitat de les Illes Balears, Palma de Mallorca, E-07122, Spain. Electronic address: tosugo@hotmail.com.
  • Moghaddam AH; Department of Biology, Faculty of Sciences, University of Mazandaran, Babolsar, Iran. Electronic address: a.hajizadeh@umz.ac.irs.
  • Khanjani S; Department of Physiology, Faculty of Biological Sciences, Shahid Behshti University, P.O. Box, 19615-1178, Tehran, 19615-1178, Iran. Electronic address: s.khanjani66@yahoo.com.
  • Di Giovanni C; Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano, 49, 80131, Napoli, Italy. Electronic address: carmen.digiovanni@unina.it.
  • Xiao J; Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau SAR, China. Electronic address: jianboxiao@yahoo.com.
  • Shirooie S; School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran. Electronic address: shirooie@gmail.com.
  • Tsetegho Sokeng AJ; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, Pavia 27100, Italy. Electronic address: aroldjorel.tseteghosokeng01@universitadipavia.it.
  • Baldi A; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, Pavia 27100, Italy. Electronic address: alessandra.baldi.alimenti@gmail.com.
  • Mannina L; Istituto di Metodologie Chimiche, Laboratorio di Risonanza Magnetica "Annalaura Segre", CNR, 00015, Monterotondo (Rome), Italy; Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P.le Aldo Moro 5, 00185, Rome, Italy. Electronic address: luisa.mannina@uniroma1.it.
  • Nabavi SM; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box, 19395-5487, Tehran, 19395-5487, Iran. Electronic address: nabavi208@gmail.com.
  • Daglia M; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, Pavia 27100, Italy. Electronic address: maria.daglia@unipv.it.
Food Chem Toxicol ; 129: 434-443, 2019 Jul.
Article em En | MEDLINE | ID: mdl-31022478
Mood disorders occur in 30% of stroke patients, and of these post-stroke depression (PSD) is the most significant. This study aimed to evaluate the antidepressive-like effects and in vivo antioxidant activity of a chemically characterized maqui berry (Aristotelia chilensis (Molina) Stuntz) extract obtained from an optimized extraction method, on a murine PSD model. The extraction process was optimized to maximize anthocyanin content, and the phytochemical profile of the extract was evaluated using a multi-methodological approach including a liquid chromatographic method coupled with mass spectrometry and nuclear magnetic resonance spectroscopy. The antidepressive-like activity was investigated through despair swimming and tail suspension tests. The in vivo antioxidant activity was evaluated in mouse brain tissue by measuring the activity of antioxidant enzymes and lipid peroxidation products. A number of compounds have been first identified in maqui berry here, including malvidin-glucoside, GABA, choline and trigonelline. Moreover, the results showed that the antidepressive-like activity exerted by the extract, which was found to restore normal mouse behavior in both despair swimming and tail suspension tests, could be linked to its antioxidant activity, leading to the conclusion that maqui berries might be useful for supporting pharmacological therapy of PSD by modulating oxidative stress.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Acidente Vascular Cerebral / Elaeocarpaceae / Depressão / Antidepressivos Tipo de estudo: Etiology_studies Limite: Animals País/Região como assunto: America do sul / Chile Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Acidente Vascular Cerebral / Elaeocarpaceae / Depressão / Antidepressivos Tipo de estudo: Etiology_studies Limite: Animals País/Região como assunto: America do sul / Chile Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido