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Antibacterial potential associated with drug-delivery built TiO2 nanotubes in biomedical implants.
Kunrath, Marcel Ferreira; Leal, Bruna Ferreira; Hubler, Roberto; de Oliveira, Sílvia Dias; Teixeira, Eduardo Rolim.
Afiliação
  • Kunrath MF; Dentistry University, School of Health Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, P.O. Box 6681, Porto Alegre, 90619-900, Brazil. marcelfkunrath@gmail.com.
  • Leal BF; Materials and Nanoscience Laboratory, Pontifical Catholic University of Rio Grande do Sul (PUCRS), P.O. Box 1429, Porto Alegre, 90619-900, Brazil. marcelfkunrath@gmail.com.
  • Hubler R; Immunology and Microbiology Laboratory, School of Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, P.O. Box 6681, Porto Alegre, 90619-900, Brazil.
  • de Oliveira SD; Materials and Nanoscience Laboratory, Pontifical Catholic University of Rio Grande do Sul (PUCRS), P.O. Box 1429, Porto Alegre, 90619-900, Brazil.
  • Teixeira ER; Immunology and Microbiology Laboratory, School of Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, P.O. Box 6681, Porto Alegre, 90619-900, Brazil.
AMB Express ; 9(1): 51, 2019 Apr 16.
Article em En | MEDLINE | ID: mdl-30993485
The fast evolution of surface treatments for biomedical implants and the concern with their contact with cells and microorganisms at early phases of bone healing has boosted the development of surface topographies presenting drug delivery potential for, among other features, bacterial growth inhibition without impairing cell adhesion. A diverse set of metal ions and nanoparticles (NPs) present antibacterial properties of their own, which can be applied to improve the implant local response to contamination. Considering the promising combination of nanostructured surfaces with antibacterial materials, this critical review describes a variety of antibacterial effects attributed to specific metals, ions and their combinations. Also, it explains the TiO2 nanotubes (TNTs) surface creation, in which the possibility of aggregation of an active drug delivery system is applicable. Also, we discuss the pertinent literature related to the state of the art of drug incorporation of NPs with antibacterial properties inside TNTs, along with the promising future perspectives of in situ drug delivery systems aggregated to biomedical implants.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: AMB Express Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: AMB Express Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha