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Bisphenol A and adiposity measures in peripubertal boys from the INMA-Granada cohort.
Mustieles, Vicente; Casas, Maribel; Ferrando-Marco, Patricia; Ocón-Hernández, Olga; Reina-Pérez, Iris; Rodríguez-Carrillo, Andrea; Vela-Soria, Fernando; Pérez-Lobato, Rocío; Navarrete-Muñoz, Eva María; Freire, Carmen; Olea, Nicolás; Fernández, Mariana F.
Afiliação
  • Mustieles V; University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto Investigación Biosanitaria Ibs GRANADA, Granada, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 18100, Spain.
  • Casas M; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 18100, Spain; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Ferrando-Marco P; Instituto Investigación Biosanitaria Ibs GRANADA, Granada, Spain.
  • Ocón-Hernández O; Instituto Investigación Biosanitaria Ibs GRANADA, Granada, Spain.
  • Reina-Pérez I; University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto Investigación Biosanitaria Ibs GRANADA, Granada, Spain.
  • Rodríguez-Carrillo A; University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto Investigación Biosanitaria Ibs GRANADA, Granada, Spain.
  • Vela-Soria F; University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto Investigación Biosanitaria Ibs GRANADA, Granada, Spain.
  • Pérez-Lobato R; Instituto Investigación Biosanitaria Ibs GRANADA, Granada, Spain.
  • Navarrete-Muñoz EM; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 18100, Spain; Department of Public Health, History of Medicine and Gynecology, Miguel Hernandez University, San Juan de Alicante, Spain.
  • Freire C; University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto Investigación Biosanitaria Ibs GRANADA, Granada, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 18100, Spain.
  • Olea N; University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto Investigación Biosanitaria Ibs GRANADA, Granada, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 18100, Spain.
  • Fernández MF; University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto Investigación Biosanitaria Ibs GRANADA, Granada, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 18100, Spain. Electronic address: marieta@ugr.es.
Environ Res ; 173: 443-451, 2019 06.
Article em En | MEDLINE | ID: mdl-30974370
INTRODUCTION: Childhood obesity is one of the most serious public health challenges of our times. Although an important body of experimental evidence highlights the obesogenic potential of endocrine disruptors such as bisphenol A (BPA), the epidemiological evidence remains inconclusive and limited. OBJECTIVE: To assess associations between urinary BPA concentrations and several adiposity measures in peripubertal boys from the Environment and Childhood (INMA) cohort in Granada, Spain. MATERIAL AND METHODS: BPA concentrations were determined in spot urine samples from 298 boys aged 9-11, and their weight, height, waist circumference, and percentage body fat mass were measured. Overweight/obesity was defined as BMI z-score ≥85th percentile and abdominal obesity as waist-to-height ratio (WHtR) ≥0.5. Associations were assessed using multivariable linear and logistic regression models. RESULTS: In adjusted models, each natural log-unit increase in urinary BPA concentrations was associated with higher BMI z-score (ß = 0.22; 95%CI = 0.03, 0.41) and increased odds of overweight/obesity (OR = 1.46; 95%CI = 1.05, 2.05). Children with higher BPA concentrations had higher WHtR values (ß = 0.007; 95%CI = -0.001, 0.015), and BPA was associated with a greater risk of abdominal obesity (OR = 1.45; 95%CI = 1.03, 2.06). No associations were found with % body fat mass. CONCLUSIONS: BPA may exert an obesogenic effect in peripubertal boys, potentially increasing the risk of overweight/obesity, especially abdominal obesity. However, these results should be interpreted with caution given the modest sample size and the possibilities of reverse causality and residual confounding by diet and lifestyle patterns.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Compostos Benzidrílicos / Exposição Ambiental / Adiposidade Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans / Male País/Região como assunto: Caribe ingles / Europa / Grenada Idioma: En Revista: Environ Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Compostos Benzidrílicos / Exposição Ambiental / Adiposidade Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans / Male País/Região como assunto: Caribe ingles / Europa / Grenada Idioma: En Revista: Environ Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha País de publicação: Holanda