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The Impact of Radiodermatitis on Breast Cancer Patients' Quality of Life During Radiotherapy: A Prospective Cohort Study.
Fuzissaki, Marceila de Andrade; Paiva, Carlos Eduardo; Oliveira, Marco Antonio de; Lajolo Canto, Paula Philbert; Paiva Maia, Yara Cristina de.
Afiliação
  • Fuzissaki MA; Graduate Program in Health Science, Medical School, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil.
  • Paiva CE; Division of Breast and Gynecology, Department of Clinical Oncology, Barretos Cancer Hospital, São Paulo, Brazil.
  • Oliveira MA; Center of Epidemiology and Biostatistics, Barretos Cancer Hospital, São Paulo, Brazil.
  • Lajolo Canto PP; Department of Clinical Oncology, Clinics Hospital, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil.
  • Paiva Maia YC; Graduate Program in Health Science, Medical School, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil. Electronic address: yara.maia@ufu.br.
J Pain Symptom Manage ; 58(1): 92-99.e1, 2019 07.
Article em En | MEDLINE | ID: mdl-30974233
CONTEXT: In the oncology field, quality of life (QoL) is recognized as an essential component. However, few studies have evaluated radiotherapy (RT) and its adverse events, specifically radiodermatitis. OBJECTIVES: The objective of this study was to investigate the influence of radiodermatitis severity on QoL of women with breast cancer (BC) throughout RT. METHODS: A prospective cohort study was conducted with 100 BC patients evaluated weekly during RT. The Dermatology Life Quality Index questionnaire and the Radiation Therapy Oncology Group scale were used. The generalized estimated equations were used to examine the association between the total score of QoL and their domains, time of RT, and the radiodermatitis score, controlled by confounding factors. Estimated marginal means and 95% CIs were compared pairwise by applying Sequential Sidak. RESULTS: The total QoL score and their domains (work/school, leisure, daily activities, symptoms, and feelings) were significantly associated with the evaluation times of RT (P < 0.001), the radiodermatitis score (P ≤ 0.002), and the interaction between timing (T) of treatment and radiodermatitis score (P < 0.001). When assessing post hoc, it was identified that the worst QoL scores were in the presence of Grade 3 (mean = 6.00) in T3 and Grade 4 (6.50; 7.00) in T5 and T6, respectively, and this difference was statistically significant. CONCLUSIONS: RT negatively influenced the QoL of women with BC, with the greatest impact resulting from severe radiodermatitis. Actions aimed at minimizing the impairment on QoL need to be adopted to make this exhausting process less traumatic and easier to complete.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Radiodermite / Neoplasias da Mama Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Aspecto: Patient_preference Limite: Female / Humans Idioma: En Revista: J Pain Symptom Manage Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA / TERAPEUTICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Radiodermite / Neoplasias da Mama Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Aspecto: Patient_preference Limite: Female / Humans Idioma: En Revista: J Pain Symptom Manage Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA / TERAPEUTICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos