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Association of expression of inflammatory response genes and DNA repair genes in colorectal carcinoma.
Germini, Demétrius Eduardo; Franco, Maria Isete Fares; Fonseca, Fernando Luiz Affonso; de Sousa Gehrke, Flávia; da Costa Aguiar Alves Reis, Beatriz; Cardili, Leonardo; Oshima, Celina Tizuko Fujiyama; Theodoro, Thérèse Rachell; Waisberg, Jaques.
Afiliação
  • Germini DE; 1 Department of Surgery, São Paulo State Civil Servant Hospital, São Paulo, Brazil.
  • Franco MIF; 2 Department of Pathology, São Paulo State Civil Servant Hospital, São Paulo, Brazil.
  • Fonseca FLA; 3 Department of Pathology, ABC School of Medicine, Santo André, Brazil.
  • de Sousa Gehrke F; 3 Department of Pathology, ABC School of Medicine, Santo André, Brazil.
  • da Costa Aguiar Alves Reis B; 3 Department of Pathology, ABC School of Medicine, Santo André, Brazil.
  • Cardili L; 4 Department of Pathology, Federal University of São Paulo, São Paulo, Brazil.
  • Oshima CTF; 4 Department of Pathology, Federal University of São Paulo, São Paulo, Brazil.
  • Theodoro TR; 5 Department of Morphology and Physiology, ABC School of Medicine, Santo André, Brazil.
  • Waisberg J; 1 Department of Surgery, São Paulo State Civil Servant Hospital, São Paulo, Brazil.
Tumour Biol ; 42(4): 1010428319843042, 2019 Apr.
Article em En | MEDLINE | ID: mdl-30973070
Inflammation is an important etiological factor of colorectal carcinoma and may be related to colorectal carcinoma growth and proliferation. This study aimed to verify whether the presence of chronic inflammation represented by tumor necrosis factor-α, interleukin-2, interleukin-6, and interleukin-10 gene expression is related to hMLH1, hMSH2, hMSH6, and PMS2 gene expression and the corresponding protein levels of these genes from the DNA repair system. A total of 83 patients were operated on for curative or palliative colorectal carcinoma. Expression of the inflammatory response genes tumor necrosis factor-α, interleukin-2, interleukin-6, and interleukin-10 as well as expression of the hMLH1, hMSH2, hMSH6, and PMS2 genes of the DNA repair system (mismatch repair) and the expression levels of the corresponding mismatch repair proteins were measured in neoplastic tissue by reverse transcription polymerase chain reaction and immunohistochemistry, respectively. Associations were observed between hMSH6 mRNA expression and interleukin-2 mRNA expression (p = 0.026) as well as between hMLH1 and hMSH2 gene expression and tumor necrosis factor-α gene expression (p = 0.042). Higher tissue levels of interleukin-2 and tumor necrosis factor-α gene expression were associated with lower hMSH6, hMLH1, and hMSH2 gene expression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proliferação de Células / Carcinogênese / Inflamação Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Tumour Biol Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proliferação de Células / Carcinogênese / Inflamação Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Tumour Biol Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda