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Apoptotic signaling in salivary mucoepidermoid carcinoma.
da Silva, Gabriela M; Saavedra, Victoria; Ianez, Renata C F; de Sousa, Elen A; Gomes, Ágatha N; Kelner, Natalie; Nagai, Maria A; Kowalski, Luiz P; Soares, Fernando A; Lourenço, Silvia V; Coutinho-Camillo, Cláudia M.
Afiliação
  • da Silva GM; International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil.
  • Saavedra V; International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil.
  • Ianez RCF; International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil.
  • de Sousa EA; International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil.
  • Gomes ÁN; International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil.
  • Kelner N; Department of Head and Neck Surgery and Otorhinolaryngology, A.C.Camargo Cancer Center, São Paulo, Brazil.
  • Nagai MA; Discipline of Oncology, Department of Radiology and Oncology, Medical School, University of São Paulo, São Paulo, Brazil.
  • Kowalski LP; Laboratory of Molecular Genetics, Center for Translational Research in Oncology, Cancer Institute of São Paulo, São Paulo, Brazil.
  • Soares FA; Department of Head and Neck Surgery and Otorhinolaryngology, A.C.Camargo Cancer Center, São Paulo, Brazil.
  • Lourenço SV; Department of General Pathology, Dental School, University of São Paulo, São Paulo, Brazil.
  • Coutinho-Camillo CM; Pathology Division, Rede D'Or Hospitals Network, São Paulo, Brazil.
Head Neck ; 41(9): 2904-2913, 2019 09.
Article em En | MEDLINE | ID: mdl-30968512
BACKGROUND: Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. Apoptosis plays an important role in organogenesis of glandular structures, and aberrations of apoptotic mechanisms is associated with a wide array of pathologic conditions. METHODS: The immunoexpression of proteins associated with apoptosis and proliferation was evaluated in 40 mucoepidermoid carcinoma cases. RESULTS: Par-4, Survivin, MUC1, PHLDA1, Fas, and Ki-67 were predominantly expressed in mucoepidermoid carcinoma. FasL was rarely expressed, and Caspase-3 expression was observed in almost 50% of the cases. SPARC expression was associated with low-grade tumors, and Ki-67 expression was associated with lymph node metastasis. Expression of Fas and decreased expression of Ki-67 and Caspase-3 were associated with better overall cancer-specific survival rates. CONCLUSIONS: The association of SPARC and Ki-67 expression with pathological features and the association of Fas, Caspase-3, and Ki-67 with survival probabilities suggest that these proteins may be useful prognostic markers for mucoepidermoid carcinoma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Apoptose / Carcinoma Mucoepidermoide Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Head Neck Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Apoptose / Carcinoma Mucoepidermoide Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Head Neck Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos