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Assessment of Beneficial and Possible Toxic Effects of Two New Alfalfa-Derived Shelf Products.
Soto-Zarazúa, María G; Bah, Moustapha; García-Alcocer, María G; Berumen, Laura C; Costa, Carla Sofia; Bessa, Maria João; Rodrigues, Francisca; Teixeira, João Paulo; Oliveira, Maria Beatriz P P.
Afiliação
  • Soto-Zarazúa MG; 1 Chemical and Biological Sciences Postgraduate Department, Faculty of Chemistry, Autonomous University of Querétaro, Querétaro, Mexico .
  • Bah M; 2 REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto , Porto, Portugal .
  • García-Alcocer MG; 1 Chemical and Biological Sciences Postgraduate Department, Faculty of Chemistry, Autonomous University of Querétaro, Querétaro, Mexico .
  • Berumen LC; 1 Chemical and Biological Sciences Postgraduate Department, Faculty of Chemistry, Autonomous University of Querétaro, Querétaro, Mexico .
  • Costa CS; 1 Chemical and Biological Sciences Postgraduate Department, Faculty of Chemistry, Autonomous University of Querétaro, Querétaro, Mexico .
  • Bessa MJ; 3 Department of Environmental Health, Portuguese National Institute of Health , Porto, Portugal .
  • Rodrigues F; 4 EPIUnit-Institute of Public Health, University of Porto , Porto, Portugal .
  • Teixeira JP; 3 Department of Environmental Health, Portuguese National Institute of Health , Porto, Portugal .
  • Oliveira MBPP; 2 REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto , Porto, Portugal .
J Med Food ; 19(10): 970-977, 2016 Oct.
Article em En | MEDLINE | ID: mdl-30913400
Aerial parts of Medicago sativa L. have been used as food and its consumption has been associated with health benefits, one among the most important being menopausal symptoms control. This work was aimed to explore possible pharmacological effects of two new alfalfa-derived products that have recently emerged as daily beverage preparations. In exploring their potential estrogenic effects, they produced no relevant alteration in the uterus. However, lowering glucose levels until normal values without causing further hypoglycemic effect were observed, when rats were treated with 1.5 g/kg/day samples. In vivo acute toxicity was not found when the alfalfa products were tested up to 3 g/kg rat weight. Furthermore, in vitro studies were conducted to assess their possible toxic effects. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase tests were carried out on the Caco-2 cell model to determine cell viability and membrane integrity. A concentration-dependent effect was observed, with a significant decrease in cell viability after exposure to concentrations of alfalfa product up to 100 mg/mL (after 3 h of incubation) and 50 mg/mL (after 24 h of treatment). Although in vitro level, the decrease in cell viability at these still low doses may underlie some toxicity, making necessary additional studies before any recommendation of a sustained consumption of these products by humans.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Revista: J Med Food Assunto da revista: CIENCIAS DA NUTRICAO / MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Revista: J Med Food Assunto da revista: CIENCIAS DA NUTRICAO / MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos