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Homeostatic model assessment of adiponectin (HOMA-Adiponectin) as a surrogate measure of insulin resistance in adolescents: Comparison with the hyperglycaemic clamp and homeostatic model assessment of insulin resistance.
da Silva, Cleliani de Cassia; Zambon, Mariana Porto; Vasques, Ana Carolina Junqueira; Camilo, Daniella Fernandes; De Bernardi Rodrigues, Ana Maria; Antonio, Maria Ângela Reis de Góes Monteiro; Dâmaso, Ana Raimunda; Tufik, Sergio; de Mello, Marco Tulio; Campos, Raquel Munhoz da Silveira; Geloneze, Bruno.
Afiliação
  • da Silva CC; Laboratory of Investigation on Metabolism and Diabetes (Limed), Gastroenterological Diagnosis and Research Center (Gastrocentro), University of Campinas - Unicamp, Campinas, São Paulo, Brazil.
  • Zambon MP; Postgraduate Program in Child and Adolescent Health, Faculty of Medical Sciences, University of Campinas - Unicamp, Campinas, São Paulo, Brazil.
  • Vasques ACJ; Postgraduate Program in Child and Adolescent Health, Faculty of Medical Sciences, University of Campinas - Unicamp, Campinas, São Paulo, Brazil.
  • Camilo DF; Department of Pediatrics, University of Campinas - Unicamp, Campinas, São Paulo, Brazil.
  • De Bernardi Rodrigues AM; Laboratory of Investigation on Metabolism and Diabetes (Limed), Gastroenterological Diagnosis and Research Center (Gastrocentro), University of Campinas - Unicamp, Campinas, São Paulo, Brazil.
  • Antonio MÂRGM; Postgraduate Program in Child and Adolescent Health, Faculty of Medical Sciences, University of Campinas - Unicamp, Campinas, São Paulo, Brazil.
  • Dâmaso AR; School of Applied Sciences, University of Campinas - Unicamp, Limeira, São Paulo, Brazil.
  • Tufik S; Laboratory of Investigation on Metabolism and Diabetes (Limed), Gastroenterological Diagnosis and Research Center (Gastrocentro), University of Campinas - Unicamp, Campinas, São Paulo, Brazil.
  • de Mello MT; Postgraduate Program in Child and Adolescent Health, Faculty of Medical Sciences, University of Campinas - Unicamp, Campinas, São Paulo, Brazil.
  • Campos RMDS; Laboratory of Investigation on Metabolism and Diabetes (Limed), Gastroenterological Diagnosis and Research Center (Gastrocentro), University of Campinas - Unicamp, Campinas, São Paulo, Brazil.
  • Geloneze B; School of Health and Life Sciences, University Center Our Lady of Patronage, Itu, São Paulo, Brazil.
PLoS One ; 14(3): e0214081, 2019.
Article em En | MEDLINE | ID: mdl-30908521
BACKGROUND: Studies on adults have reported inverse association between the homeostatic model assessment (HOMA) of adiponectin (HOMA-Adiponectin) and the insulin resistance assessed by the glucose clamp technique. To our knowledge, in the pediatric population this association has not been previously investigated. OBJECTIVES: To evaluate the association between the HOMA-Adiponectin and the insulin resistance assessed by the glucose clamp technique in adolescents, and to compare the accuracy of HOMA-Adiponectin and HOMA-insulin resistance (HOMA-IR) for identifying insulin resistance. METHODS: This was a cross-sectional study of 56 adolescents (aged 10-18 years). Insulin resistance was assessed using the HOMA-IR, HOMA-Adiponectin and the hyperglycaemic clamp technique. The clamp-derived insulin sensitivity index, HOMA-Adiponectin, and HOMA-IR were log-transformed to get closer to a normal distribution before analysis. RESULTS: In the multivariable linear regression analysis controlling for sex and Tanner stage, HOMA-Adiponectin was inversely associated with the clamp-derived insulin sensitivity index (unstandardized coefficient [B] = -0.441; P < 0.001). After additional adjustment for waist circumference-to-height ratio, this association remained significant (B = -0.349; P = < 0.001). Similar results were observed when HOMA-IR replaced HOMA-Adiponectin in the model (B = -1.049 and B = -0.968 after additional adjustment for waist circumference-to-height ratio); all P < 0.001. The area under the receiver operating characteristic curve for predicting insulin resistance was 0.712 (P = 0.02) for HOMA-Adiponectin and 0.859 (P < 0.0001) HOMA-IR. CONCLUSIONS: The HOMA-Adiponectin was independently associated with insulin resistance and exhibited a good discriminatory power for predicting it. However, it did not show superiority over HOMA-IR in the diagnostic accuracy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Adiponectina / Homeostase / Modelos Biológicos Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Adiponectina / Homeostase / Modelos Biológicos Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos