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Rapid Detection of Sepsis using CESDA: the Caenorhabditis elegans Sepsis Detection Assay.
Tee, Ling Fei; Tan, Toh Leong; Neoh, Hui-Min; Jamal, Rahman.
Afiliação
  • Tee LF; UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Malaysia.
  • Tan TL; Department of Emergency Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Malaysia.
  • Neoh HM; UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Malaysia.
  • Jamal R; UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Malaysia.
Rev Soc Bras Med Trop ; 52: e20180300, 2019 Mar 14.
Article em En | MEDLINE | ID: mdl-30892548
INTRODUCTION: The nematode Caenorhabditis elegans was used as a biological sensor to detect the urine of sepsis patients (CESDA assay). METHODS: C. elegans was aliquoted onto the center of assay plates and allowed to migrate towards sepsis (T) or control (C) urine samples spotted on the same plate. The number of worms found in either (T) or (C) was scored at 10-minute intervals over a 60-minute period. RESULTS: The worms were able to identify the urine (<48 hours) of sepsis patients rapidly within 20 minutes (AUROC=0.67, p=0.012) and infection within 40 minutes (AUROC=0.80, p=0.016). CONCLUSIONS: CESDA could be further explored for sepsis diagnosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Quimiotaxia / Caenorhabditis elegans / Sepse Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Rev Soc Bras Med Trop Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Malásia País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Quimiotaxia / Caenorhabditis elegans / Sepse Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Rev Soc Bras Med Trop Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Malásia País de publicação: Brasil