Your browser doesn't support javascript.
loading
Prevalence and genetic diversity of viral gastroenteritis viruses in children younger than 5 years of age in Guatemala, 2014-2015.
Diez-Valcarce, Marta; Lopez, Maria Renee; Lopez, Beatriz; Morales, Oneida; Sagastume, Manuel; Cadena, Loren; Kaydos-Daniels, Susan; Jarquin, Claudia; McCracken, John P; Bryan, Joe P; Vinjé, Jan.
Afiliação
  • Diez-Valcarce M; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
  • Lopez MR; Universidad del Valle de Guatemala, Guatemala City, Guatemala.
  • Lopez B; Universidad del Valle de Guatemala, Guatemala City, Guatemala.
  • Morales O; Universidad del Valle de Guatemala, Guatemala City, Guatemala.
  • Sagastume M; Department of Epidemiology, Ministry of Public Health and Social Welfare, Guatemala City, Guatemala.
  • Cadena L; Division of Global Health Protection, US Centers for Disease Control and Prevention, Atlanta, GA; Central American Regional Office, Centers for Disease Control and Prevention, Guatemala City, Guatemala.
  • Kaydos-Daniels S; Influenza Program, US Centers for Disease Control and Prevention, Guatemala City, Guatemala.
  • Jarquin C; Universidad del Valle de Guatemala, Guatemala City, Guatemala.
  • McCracken JP; Universidad del Valle de Guatemala, Guatemala City, Guatemala.
  • Bryan JP; Division of Global Health Protection, US Centers for Disease Control and Prevention, Atlanta, GA; Central American Regional Office, Centers for Disease Control and Prevention, Guatemala City, Guatemala.
  • Vinjé J; Division of Viral Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: jvinje@cdc.gov.
J Clin Virol ; 114: 6-11, 2019 05.
Article em En | MEDLINE | ID: mdl-30875613
BACKGROUND: Acute diarrhea is an important cause of morbidity and mortality in children and is associated with approximately 500,000 deaths/year globally. Rotavirus and norovirus are leading causes of acute diarrhea accounting for more than half of this burden. OBJECTIVE/STUDY DESIGN: To determine the prevalence and genotype distribution of acute diarrhea caused by rotavirus, norovirus, sapovirus and astrovirus among children <5 years of age at two departments in Guatemala from January 2014 to December 2015, we tested 471 stool specimens (202 samples from hospitalized children and 269 samples from children in ambulatory clinics) by real-time reverse transcription-PCR and genotyped positive samples. RESULTS: Rotavirus was detected in 20.4%, norovirus in 18.5%, sapovirus in 7% and astrovirus in 4.2% of the samples. Co-infection of rotavirus and norovirus was found in 2.6% of the samples. Most norovirus (87.4%) and rotavirus (81.3%) infections were detected in children in the 6-12 months age group. The proportion of patients with rotavirus (34%) and norovirus (23%) was higher in hospitalized patients compared to ambulatory patients, whereas the prevalence of sapovirus and astrovirus was similar in both settings. Of the 40 genotyped norovirus strains, 62.5% were GII.4 and 15% GII.3. Sapovirus genotypes included GI.1 (15.4%), GII.2 (15.4%), GII.5 (38.5%) and GIV.1 (30.8%). CONCLUSIONS: Our data demonstrate that in 2014-2015, gastroenteritis viruses account for 50% of acute diarrhea in children younger than 5 years of age in Guatemala, highlighting the importance of continuous surveillance to guide impact of the current rotavirus vaccine and formulation of future norovirus vaccines.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus de RNA / Variação Genética / Gastroenterite Tipo de estudo: Prevalence_studies / Risk_factors_studies Limite: Child, preschool / Female / Humans / Infant / Male / Newborn País/Região como assunto: America central / Guatemala Idioma: En Revista: J Clin Virol Assunto da revista: VIROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus de RNA / Variação Genética / Gastroenterite Tipo de estudo: Prevalence_studies / Risk_factors_studies Limite: Child, preschool / Female / Humans / Infant / Male / Newborn País/Região como assunto: America central / Guatemala Idioma: En Revista: J Clin Virol Assunto da revista: VIROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda