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Synthesis and in vitro testing of thermoresponsive polymer-grafted core-shell magnetic mesoporous silica nanoparticles for efficient controlled and targeted drug delivery.
Peralta, Marcos E; Jadhav, Sushilkumar A; Magnacca, Giuliana; Scalarone, Dominique; Mártire, Daniel O; Parolo, María E; Carlos, Luciano.
Afiliação
  • Peralta ME; Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas, PROBIEN (CONICET-UNCo), Facultad de Ingeniería, Universidad Nacional del Comahue, Buenos Aires 1400, 8300 Neuquén, Argentina.
  • Jadhav SA; Department of Chemistry and NIS centre, University of Torino, Via P. Giuria 7, 10125 Torino, Italy; School of Nanoscience and Technology, Shivaji University Kolhapur, 416004 Kolhapur, Maharashtra, India. Electronic address: sushil.unige@gmail.com.
  • Magnacca G; Department of Chemistry and NIS centre, University of Torino, Via P. Giuria 7, 10125 Torino, Italy.
  • Scalarone D; Department of Chemistry and NIS centre, University of Torino, Via P. Giuria 7, 10125 Torino, Italy.
  • Mártire DO; Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), CCT-La Plata- CONICET, Universidad Nacional de La Plata, 1900 La Plata, Argentina.
  • Parolo ME; Centro de Investigaciones en Toxicología Ambiental y Agrobiotecnología del Comahue, CITAAC (CONICET-UNCo), Facultad de Ingeniería, Universidad Nacional Del Comahue, Buenos Aires 1400, 8300 Neuquén, Argentina.
  • Carlos L; Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas, PROBIEN (CONICET-UNCo), Facultad de Ingeniería, Universidad Nacional del Comahue, Buenos Aires 1400, 8300 Neuquén, Argentina. Electronic address: luciano.carlos@probien.gob.ar.
J Colloid Interface Sci ; 544: 198-205, 2019 May 15.
Article em En | MEDLINE | ID: mdl-30844568
In this work, thermoresponsive polymer grafted magnetic mesoporous silica nanoparticles were prepared, fully characterized and tested as controlled drug delivery systems. For this purpose, iron oxide nanoparticles coated with mesoporous silica shell were grafted with poly(N-isopropylacrylamide-co-3-(methacryloxypropyl)trimethoxysilane) (PNIPAM-co-MPS). The grafting and polymerization on the as-prepared nanoparticles were performed in one-step procedure. Using this methodology, the polymer was successfully grafted mainly onto the silica surface, leaving the mesopores empty for the drug loading. The prepared hybrid nanoparticles (MMSNP-PNIPAM-co-MPS) showed high magnetization saturation (19.5 emu g-1) and high specific surface area (505 m2 g-1) and pore volume (0.29 cm3 g-1). Ibuprofen was used as a model drug to test the performance of the hybrid particles as thermosensitive drug delivery systems. For this, in vitro drug delivery tests were conducted below (25 °C) and above (40 °C) the lower critical solution temperature (LCST) of the polymer (PNIPAM-co-MPS). Considerable difference (80%) in the ibuprofen release at these two temperatures and a fast and complete release of the drug at 40 °C was observed. These results suggest that the thermoresponsive copolymer acts as a gatekeeper for the temperature-controlled release of the drug loaded inside the mesopores. Therefore, MMSNP-PNIPAM-co-MPS are promising magnetic and thermoresponsive nanocarriers for targeted delivery of therapeutic substances.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Silanos / Resinas Acrílicas / Portadores de Fármacos / Dióxido de Silício / Nanopartículas de Magnetita / Metacrilatos Idioma: En Revista: J Colloid Interface Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Silanos / Resinas Acrílicas / Portadores de Fármacos / Dióxido de Silício / Nanopartículas de Magnetita / Metacrilatos Idioma: En Revista: J Colloid Interface Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos