Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity.
Behav Brain Res
; 365: 190-197, 2019 06 03.
Article
em En
| MEDLINE
| ID: mdl-30844418
Alzheimer's disease (AD) is characterized by the presence of amyloid-ß (Aß), oxidative damage and neuronal degeneration, which, together with other pathological events, promote progressive memory loss and cognitive decline. Non-pharmacological strategies have been study to provide some protection against the development of AD. Considering that physical exercise neuroprotective effects on prevention of cognitive deficits are well elucidate, it is important clarify the effects of cognitive training, and verify if they are similar or comparable to those observed for physical exercise. Here we divided male adult Wistar rats in six groups: control, which rats were not submitted to any intervention; Aß, which rats were submitted to hippocampal infusion of Aß; physical exercise (PE), which rats were submitted to 4 weeks of PE training; PE + Aß, which rats were submitted to 4 weeks of PE training followed by hippocampal infusion of Aß; cognitive exercise (CE), which rats were submitted to 4 weeks of CE training; and, CE + Aß, which rats were submitted to 4 weeks of CE training followed by hippocampal infusion of Aß. Ten days after Aß infusion, short (STM) and long-term (LTM) object recognition memory, as well as hippocampal oxidative stress (ROS levels by DCFH test), lipid peroxidation (TBARS), total antioxidant capacity (FRAP) and hippocampal histology were evaluated. Both PE and CE were effective in protect cognitive function against memory deficits related to Aß neurotoxicity, preventing oxidative stress and damage and hippocampal cellular disorganization. So, cognitive training seems to be as good as physical training in the prevention of memory deficits related to Aß and seems to share some mechanisms of actions, as oxidative stress prevention.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
/
Cognição
/
Doença de Alzheimer
Limite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Holanda