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Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity.
Rossi Dare, Leticia; Garcia, Alexandre; Alves, Niege; Ventura Dias, Daniel; de Souza, Mauren Assis; Mello-Carpes, Pâmela B.
Afiliação
  • Rossi Dare L; Physiology Research Group, Federal University of Pampa, Multicentric Graduate Program in Physiological Sciences - SBFis/Unipampa, Uruguaiana, RS, Brazil.
  • Garcia A; Physiology Research Group, Federal University of Pampa, Multicentric Graduate Program in Physiological Sciences - SBFis/Unipampa, Uruguaiana, RS, Brazil.
  • Alves N; Physiology Research Group, Federal University of Pampa, Multicentric Graduate Program in Physiological Sciences - SBFis/Unipampa, Uruguaiana, RS, Brazil.
  • Ventura Dias D; Department of Structural Biology, Federal University of Triangulo Mineiro, Uberaba, MG, Brazil.
  • de Souza MA; Physiology Research Group, Federal University of Pampa, Multicentric Graduate Program in Physiological Sciences - SBFis/Unipampa, Uruguaiana, RS, Brazil.
  • Mello-Carpes PB; Physiology Research Group, Federal University of Pampa, Multicentric Graduate Program in Physiological Sciences - SBFis/Unipampa, Uruguaiana, RS, Brazil. Electronic address: pamelacarpes@unipampa.edu.br.
Behav Brain Res ; 365: 190-197, 2019 06 03.
Article em En | MEDLINE | ID: mdl-30844418
Alzheimer's disease (AD) is characterized by the presence of amyloid-ß (Aß), oxidative damage and neuronal degeneration, which, together with other pathological events, promote progressive memory loss and cognitive decline. Non-pharmacological strategies have been study to provide some protection against the development of AD. Considering that physical exercise neuroprotective effects on prevention of cognitive deficits are well elucidate, it is important clarify the effects of cognitive training, and verify if they are similar or comparable to those observed for physical exercise. Here we divided male adult Wistar rats in six groups: control, which rats were not submitted to any intervention; Aß, which rats were submitted to hippocampal infusion of Aß; physical exercise (PE), which rats were submitted to 4 weeks of PE training; PE + Aß, which rats were submitted to 4 weeks of PE training followed by hippocampal infusion of Aß; cognitive exercise (CE), which rats were submitted to 4 weeks of CE training; and, CE + Aß, which rats were submitted to 4 weeks of CE training followed by hippocampal infusion of Aß. Ten days after Aß infusion, short (STM) and long-term (LTM) object recognition memory, as well as hippocampal oxidative stress (ROS levels by DCFH test), lipid peroxidation (TBARS), total antioxidant capacity (FRAP) and hippocampal histology were evaluated. Both PE and CE were effective in protect cognitive function against memory deficits related to Aß neurotoxicity, preventing oxidative stress and damage and hippocampal cellular disorganization. So, cognitive training seems to be as good as physical training in the prevention of memory deficits related to Aß and seems to share some mechanisms of actions, as oxidative stress prevention.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Cognição / Doença de Alzheimer Limite: Animals Idioma: En Revista: Behav Brain Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Cognição / Doença de Alzheimer Limite: Animals Idioma: En Revista: Behav Brain Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda