Your browser doesn't support javascript.
loading
Preconception immunization can modulate intracellular Th2 cytokine profile in offspring: in vivo influence of interleukin 10 and B/T cell collaboration.
de Oliveira, Marília Garcia; Lira, Aline Aparecida de Lima; Sgnotto, Fábio da Ressureição; Inoue, Amanda Harumi Sabô; Duarte, Alberto José da Silva; Victor, Jefferson Russo.
Afiliação
  • de Oliveira MG; Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Lira AAL; Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Sgnotto FDR; Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Inoue AHS; Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Duarte AJDS; Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Victor JR; Division of Pathology, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
Cent Eur J Immunol ; 43(4): 378-388, 2018.
Article em En | MEDLINE | ID: mdl-30799985
INTRODUCTION: In the last few years our group has been studying the mechanisms involved in the inhibition of allergy in offspring mediated by preconception maternal immunization, but these mechanisms are not fully understood. Such mechanisms that we have studied aimed at the passive transfer of maternal antibodies and its influence on offspring immune status. AIM OF THE STUDY: To evaluate whether maternal immunization could modulate intracellular Th1/Th2 profiles in offspring. MATERIAL AND METHODS: C57BL/6 female wild type mice (WT), interleukin (IL)-10-/- or CD28-/- mice were immunized or not with ovalbumin (OVA) and were mated with respective lineage males and offspring were evaluated at 3 days old (d.o.), 20 d.o., or 20 d.o. after neonatal immunization. RESULTS: Preconception OVA immunization induced a marked reduction in IL-4 secretion by TCD4+ cells of WT offspring when compared with offspring from non-immunized mothers. The maternal immunization of IL-10-/- mice induced an increase in the TCD4+IL-4+ percentage in offspring and a reduction in TCD4+IFN-γ+ cells. The maternal immunization in CD28-/- mice induced augment IL-4 intensity in 3 and 20 d.o. offspring TCD4+ cells. CONCLUSIONS: Our results reveal that maternal immunization with OVA can down-regulate the Th2 pattern in offspring and this regulation is dependent on IL-10 and B/T cell collaboration.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cent Eur J Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Polônia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cent Eur J Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Polônia