Your browser doesn't support javascript.
loading
Investigation of three oncogenic epitheliotropic viruses shows human papillomavirus in association with non-melanoma skin cancer.
Baez, Camila Freze; Gonçalves, Marianna Tavares Venceslau; da Rocha, Willker Menezes; Magalhães de Souza, Leandro; Savassi-Ribas, Flavia; de Oliveira Almeida, Núbia Karla; Delbue, Serena; Guimarães, Maria Angelica Arpon Marandino; Cavalcanti, Silvia Maria Baeta; Luz, Flávio Barbosa; Varella, Rafael Brandão.
Afiliação
  • Baez CF; Department of Preventive Medicine, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Gonçalves MTV; Department of Preventive Medicine, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • da Rocha WM; Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Rio de Janeiro, Brazil.
  • Magalhães de Souza L; Department of Preventive Medicine, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Savassi-Ribas F; Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Rio de Janeiro, Brazil.
  • de Oliveira Almeida NK; Department of Statistics, Federal Fluminense University, Rio de Janeiro, Brazil.
  • Delbue S; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
  • Guimarães MAAM; Department of Preventive Medicine, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Cavalcanti SMB; Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Rio de Janeiro, Brazil.
  • Luz FB; Department of Clinical Medicine, University Hospital Antônio Pedro, Federal Fluminense University, Rio de Janeiro, Brazil.
  • Varella RB; Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Rio de Janeiro, Brazil. rvarella@id.uff.br.
Eur J Clin Microbiol Infect Dis ; 38(6): 1129-1133, 2019 Jun.
Article em En | MEDLINE | ID: mdl-30788731
Non-melanoma skin cancers (NMSC) share similar risk factors with other virus-related cancers, despite the lack of proved causal association between viral infection and NMSC development. We investigated the presence of Merkel cell polyomavirus (MCPyV), Epstein-Barr virus (EBV), and human papillomavirus (HPV) DNA in 83 NMSC fresh-frozen and 16 non-cancerous skin biopsies and evaluated viral infection according to demographical data, histopathological diagnosis, and ultraviolet exposure. Our results showed that 75% of NMSC biopsies were positive for at least one out of three viruses, whereas only 38% of non-cancerous skin biopsies were positive (p = 0.02). Notably, HPV detection was frequent in NMSC (43%) and nearly absent (one sample, 6.7%) in non-cancerous biopsies (p = 0.007). MCPyV was associated with sites of higher exposure to ultraviolet radiation (p = 0.010), while EBV was associated with a compromised immune system (p = 0.032). Our study showed that HPV was strongly associated with NMSC while EBV and MCPyV with other risk factors. Though further studies are required to elucidate the role of viral infection in NMSC development and management, this study supports the possible role of oncogenic viruses in skin cancers, especially HPV.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Neoplasias Cutâneas / Infecções Tumorais por Vírus Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Clin Microbiol Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Neoplasias Cutâneas / Infecções Tumorais por Vírus Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Clin Microbiol Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha