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GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function.
Fachim, Helene A; Loureiro, Camila M; Corsi-Zuelli, Fabiana; Shuhama, Rosana; Louzada-Junior, Paulo; Menezes, Paulo Rossi; Dalton, Caroline F; Del-Ben, Cristina Marta; Reynolds, Gavin P.
Afiliação
  • Fachim HA; Department of Neurosciences & Behaviour, Ribeirão Preto Medical School, University of São Paulo, Brazil.
  • Loureiro CM; Biomolecular Sciences Research Centre, Sheffield Hallam University, UK.
  • Corsi-Zuelli F; Department of Internal Medicine, Division of Clinical Immunology, Ribeirão Preto Medical School, University of São Paulo, Brazil.
  • Shuhama R; Population Mental Health Center, University of São Paulo, Brazil.
  • Louzada-Junior P; Department of Neurosciences & Behaviour, Ribeirão Preto Medical School, University of São Paulo, Brazil.
  • Menezes PR; Department of Neurosciences & Behaviour, Ribeirão Preto Medical School, University of São Paulo, Brazil.
  • Dalton CF; Population Mental Health Center, University of São Paulo, Brazil.
  • Del-Ben CM; Biomolecular Sciences Research Centre, Sheffield Hallam University, UK.
  • Reynolds GP; Population Mental Health Center, University of São Paulo, Brazil.
Epigenomics ; 11(4): 401-410, 2019 02.
Article em En | MEDLINE | ID: mdl-30785307
AIM: We investigated GRIN1 and GRIN2B promoter methylation in first-episode schizophrenia patients compared with siblings and controls, testing for correlations between DNA methylation, cognitive performance and clinical variables. MATERIALS & METHODS: Blood-derived DNA from all groups underwent bisulfite conversion and pyrosequencing to determine methylation at CpG sites within the GRIN1 and GRIN2B promoters and results were compared with the measure of global methylation LINE-1. RESULTS: We found hypomethylation among all CpGs analyzed within GRIN2B promoter in patients and greater LINE-1 methylation in patients and siblings. CpG4 was correlated to a measure of intellectual function. CONCLUSION: Changes in GRIN2B promoter methylation may represent an environmental influence contributing to glutamatergic dysfunction in psychosis and relate to lower cognitive performance in subjects with first-episode schizophrenia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Psicologia do Esquizofrênico / Regiões Promotoras Genéticas / Receptores de N-Metil-D-Aspartato / Metilação de DNA / Predisposição Genética para Doença Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Epigenomics Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Psicologia do Esquizofrênico / Regiões Promotoras Genéticas / Receptores de N-Metil-D-Aspartato / Metilação de DNA / Predisposição Genética para Doença Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Epigenomics Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido