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First Detection of DS-1-like G1P[8] Double-gene Reassortant Rotavirus Strains on The American Continent, Brazil, 2013.
Luchs, Adriana; da Costa, Antonio Charlys; Cilli, Audrey; Komninakis, Shirley Cavalcante Vasconcelos; Carmona, Rita de Cássia Compagnoli; Morillo, Simone Guadagnucci; Sabino, Ester Cerdeira; Timenetsky, Maria do Carmo Sampaio Tavares.
Afiliação
  • Luchs A; Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, São Paulo, Brazil. driluchs@gmail.com.
  • da Costa AC; LIM/46 - Laboratory of Medical Parasitology, Department of Infectious and Parasitic Diseases, College of Medicine, University of São Paulo, São Paulo, Brazil.
  • Cilli A; Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
  • Komninakis SCV; Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, São Paulo, Brazil.
  • Carmona RCC; Postgraduate Program in Health Science, Faculty of Medicine of ABC, Santo André, Brazil.
  • Morillo SG; Retrovirology Laboratory, Federal University of São Paulo, São Paulo, São Paulo, Brazil.
  • Sabino EC; Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, São Paulo, Brazil.
  • Timenetsky MDCST; Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, São Paulo, Brazil.
Sci Rep ; 9(1): 2210, 2019 02 18.
Article em En | MEDLINE | ID: mdl-30778110
Emergence of DS-1-like-G1P[8] rotavirus in Asia have been recently reported. We report for the first time the detection and the whole genome phylogenetic analysis of DS-1-like-G1P[8] strains in America. From 2013 to 2017, a total of 4226 fecal samples were screened for rotavirus by ELISA, PAGE, RT-PCR and sequencing. G1P[8] represented 3.7% (30/800) of all rotavirus-positive samples. DS-1-like-G1P[8] comprised 1.6% (13/800) detected exclusively in 2013, and Wa-like-G1P[8] comprised 2.1% (17/800) detected from 2013 to 2015. Whole genome sequencing confirmed the DS-1-like backbone I2-R2-C2-M2-A2-N2-T2-E2-H2. All genome segments of the Brazilian DS-1-like-G1P[8] strains clustered with those of Asian strains, and apart from African DS-1-like-G1P[8] strains. In addition, Brazilian DS-1-like-G1P[8] reassortants distantly clustered with DS-1-like backbone strains simultaneously circulating in the country, suggesting that the Brazilian DS-1-like-G1P[8] strains are likely imported from Asia. Two distinct NSP4 E2 genotype lineages were also identified, indicating the existence of a co-circulating pool of different DS-1-like G1P[8] strains. Surveillance systems must be developed to examine if RVA vaccines are still effective for the prevention against unusual DS-1-like-G1P[8] strains.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Vírus Reordenados / Rotavirus / Genes Virais Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Vírus Reordenados / Rotavirus / Genes Virais Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido