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Early lead exposure and pubertal development in a Mexico City population.
Liu, Yun; Téllez-Rojo, Martha M; Sánchez, Brisa N; Zhang, Zhenzhen; Afeiche, Myriam C; Mercado-García, Adrianna; Hu, Howard; Meeker, John D; Peterson, Karen E.
Afiliação
  • Liu Y; Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Téllez-Rojo MM; Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico. Electronic address: mmtellez@insp.mx.
  • Sánchez BN; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Zhang Z; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Afeiche MC; Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
  • Mercado-García A; Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico.
  • Hu H; Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA; Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
  • Meeker JD; Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Peterson KE; Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Environ Int ; 125: 445-451, 2019 04.
Article em En | MEDLINE | ID: mdl-30763831
BACKGROUND: Previous studies have examined the association between blood lead levels and pubertal timing in adolescent girls; however, the evidence is lacking on the role of lead exposure during sensitive developmental periods on sexual maturation. OBJECTIVES: To examine the association of prenatal and early childhood lead exposure with pubertal stages among 264 boys and 283 girls aged 9.8-18.0 years in Mexico City. METHODS: We measured maternal bone lead (a proxy for cumulative fetal exposure to lead from maternal bone stores mobilized during pregnancy) at 1 month postpartum. Blood lead was measured annually from 1 to 4 years. Pubertal stage was assessed by a pediatrician. We examined the association between lead and pubertal stages of breast, pubic hair and genitalia using ordinal regression. Age at menarche was evaluated using Cox proportional-hazard models. RESULTS: Multivariate models showed that maternal patella lead and early childhood blood lead were inversely associated with breast growth (patella OR = 0.72, 95% CI: 0.51-1.00; blood OR = 0.70, 95% CI: 0.53-0.93) in girls. Girls with maternal patella lead in the 3rd tertile and child blood lead in the 2nd tertile had a later age at menarche compared with girls in the 1st tertile (patella HR = 0.60, 95% CI: 0.41-0.88; blood HR = 0.65, 95% CI 0.46-0.91). Additionally, early childhood blood lead was negatively associated with pubic hair growth (OR = 0.68, 95% CI: 0.51-0.90) in girls. No associations were found in boys. CONCLUSIONS: These data suggest that higher prenatal and early childhood exposure to lead may be associated with delayed pubertal development in girls but not boys. Our findings are consistent with previous analyses and reinforce the reproductive effects of lead for girls.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Maturidade Sexual / Puberdade / Exposição Materna / Poluentes Ambientais / Chumbo Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male / Pregnancy País/Região como assunto: Mexico Idioma: En Revista: Environ Int Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Maturidade Sexual / Puberdade / Exposição Materna / Poluentes Ambientais / Chumbo Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male / Pregnancy País/Região como assunto: Mexico Idioma: En Revista: Environ Int Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda