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Maternal bisphenol A exposure disrupts spermatogenesis in adult rat offspring.
Campos, Patricia De; Oliveira, Isabela M; Sena de Souza, Janaina; Da Conceição, Rodrigo Rodrigues; Giannocco, Gisele; Chiamolera, Maria I; Silva, Magnus R Dias-Da; Romano, Marco A; Romano, Renata Marino.
Afiliação
  • Campos P; a Laboratory of Reproductive Toxicology, Department of Pharmacy , State University of Centro-Oeste , Parana , Brazil.
  • Oliveira IM; a Laboratory of Reproductive Toxicology, Department of Pharmacy , State University of Centro-Oeste , Parana , Brazil.
  • Sena de Souza J; b Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina , Universidade Federal de São Paulo (Unifesp/EPM) , São Paulo , Brazil.
  • Da Conceição RR; b Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina , Universidade Federal de São Paulo (Unifesp/EPM) , São Paulo , Brazil.
  • Giannocco G; b Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina , Universidade Federal de São Paulo (Unifesp/EPM) , São Paulo , Brazil.
  • Chiamolera MI; b Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina , Universidade Federal de São Paulo (Unifesp/EPM) , São Paulo , Brazil.
  • Silva MRD; b Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina , Universidade Federal de São Paulo (Unifesp/EPM) , São Paulo , Brazil.
  • Romano MA; a Laboratory of Reproductive Toxicology, Department of Pharmacy , State University of Centro-Oeste , Parana , Brazil.
  • Romano RM; a Laboratory of Reproductive Toxicology, Department of Pharmacy , State University of Centro-Oeste , Parana , Brazil.
J Toxicol Environ Health A ; 82(3): 163-175, 2019.
Article em En | MEDLINE | ID: mdl-30755151
Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) that is widely used in the manufacturing of plastics and inner linings of food cans. Previously, it was reported that BPA disturbed the sexual dimorphic nucleus of the hypothalamus and delaying the onset of puberty attributed to an estrogenic action. In addition, BPA during the perinatal period increased LH serum concentrations in male offspring of dams at doses below the reproductive NOAEL (No Observable Adverse Effect Level) based upon World Health Organization guidelines. Based upon these findings, the objective of this study was to (1) determine the effects of perinatal treatment with low doses of BPA on regulation of spermatogenesis in adult offspring and (2) elucidate molecular mechanisms involved in the pathogenesis of gonadal dysfunction. The expression of genes related to spermatogenesis was disrupted with adverse consequences on sperm production, reserves, and function. Both BPA treated groups exhibited reduction in sperm production and epithelial height of seminiferous tubules, accompanied by diminished integrity of the acrosome and plasma membrane, decreased mitochondrial activity and increased incidence of morphological abnormalities. The sperm transit time was also slower. However, only in the group receiving the higher BPA dose was transcript expression of genes affected (reduced Ar and increased Esr1). It is of interest that serum testosterone levels were elevated in the same group where Ar was decreased. Data suggest that exposure to low BPA doses during hypothalamic sexual differentiation period produces permanent deleterious effects on spermatogenesis in adulthood.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Espermatogênese / Compostos Benzidrílicos / Exposição Materna / Disruptores Endócrinos Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: J Toxicol Environ Health A Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Espermatogênese / Compostos Benzidrílicos / Exposição Materna / Disruptores Endócrinos Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: J Toxicol Environ Health A Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido