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Modulation of tonic immobility by GABAA and GABAB receptors of the medial amygdala.
de Paula, Bruna B; de Melo, Jeanne R; Leite-Panissi, Christie R A.
Afiliação
  • de Paula BB; Department of Psychology, School of Philosophy, Science and Literature of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-901, SP, Brazil.
  • de Melo JR; Department of Psychology, School of Philosophy, Science and Literature of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-901, SP, Brazil.
  • Leite-Panissi CRA; Department of Psychology, School of Philosophy, Science and Literature of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-901, SP, Brazil. Electronic address: christie@usp.br.
Neurosci Lett ; 699: 189-194, 2019 04 23.
Article em En | MEDLINE | ID: mdl-30753913
Tonic immobility (TI) is a temporary state of profound motor inhibition associated with great danger as the attack of a predator. Previous studies carried out in our laboratory evidenced high Fos-IR in the posteroventral region of the medial nucleus of the amygdala (MEA) after induction of the TI response. Here, we investigated the effects of GABAA and GABAB of the MEA on TI duration. Intra-MEA injections of the GABAA agonist muscimol and GABAB agonist baclofen reduced TI response, while intra-MEA injections of the GABAA antagonist bicuculline and GABAB antagonist phaclofen increased the TI response. Moreover, the effects observed with muscimol and baclofen administrations into MEA were blocked by pretreatment with bicuculline and phaclofen (at ineffective doses per se). Finally, the activation of GABAA and GABAB receptors in the MEA did not alter the spontaneous motor activity in the open field test. These data support the role of the GABAergic system of the MEA in the modulation of innate fear.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resposta de Imobilidade Tônica / Agonistas de Receptores de GABA-A / Agonistas dos Receptores de GABA-B / Complexo Nuclear Corticomedial Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resposta de Imobilidade Tônica / Agonistas de Receptores de GABA-A / Agonistas dos Receptores de GABA-B / Complexo Nuclear Corticomedial Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda