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Weight Gain Trajectories from Birth to Adolescence and Cardiometabolic Status in Adolescence.
Barraclough, Jennifer Y; Garden, Frances L; Toelle, Brett G; Marks, Guy B; Baur, Louise A; Ayer, Julian G; Celermajer, David S.
Afiliação
  • Barraclough JY; Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia; Heart Research Institute, Sydney, Australia. Electronic address: Jennifer.Barraclough@hri.org.au.
  • Garden FL; Woolcock Institute of Medical Research, Glebe, New South Wales, Australia; South Western Sydney Clinical School, University of New South Wales, Sydney, Australia; Ingham Institute of Applied Medical Research, Sydney, Australia.
  • Toelle BG; Woolcock Institute of Medical Research, Glebe, New South Wales, Australia; Sydney Local Health District, New South Wales, Australia.
  • Marks GB; Woolcock Institute of Medical Research, Glebe, New South Wales, Australia; South Western Sydney Clinical School, University of New South Wales, Sydney, Australia; Ingham Institute of Applied Medical Research, Sydney, Australia.
  • Baur LA; University of Sydney, Discipline of Child and Adolescent Health, The Children's Hospital at Westmead Clinical School, Westmead, New South Wales, Australia.
  • Ayer JG; University of Sydney, Discipline of Child and Adolescent Health, The Children's Hospital at Westmead Clinical School, Westmead, New South Wales, Australia; The Heart Center for Children, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
  • Celermajer DS; Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia; Heart Research Institute, Sydney, Australia.
J Pediatr ; 208: 89-95.e4, 2019 05.
Article em En | MEDLINE | ID: mdl-30738659
OBJECTIVE: To assess the influence of the trajectory of weight gain from birth to adolescence on cardiovascular and metabolic risk. We studied childhood body mass index (BMI) trajectories from birth to age 14 years and cardiometabolic risk factors at age 14 years. STUDY DESIGN: In total, 410 children with weight and height measurements were assessed from birth throughout childhood, from the Childhood Asthma Prevention Study, a prospective community-based cohort. BMI trajectory groups were determined by latent basis growth mixture models. Of these subjects, 190 had detailed cardiometabolic risk factors assessed at age 14 years. RESULTS: Three BMI trajectory groups were identified; normal BMI, "early rising" excess BMI from 2 years, and "late rising" excess BMI from 5 years. Differences were found between normal and excess BMI in children at 14 years of age. In addition, children with an early rising BMI trajectory had statistically significantly higher central adiposity and a more atherogenic lipoprotein profile at age 14 years than children with a late rising BMI trajectory (P < .05). No differences between BMI trajectory groups in vascular structure or function was identified at age 14 years. CONCLUSIONS: Earlier onset of an elevated BMI trajectory persisting from birth to age 14 years results in an unfavorable cardiometabolic risk profile at age 14 years, including central adiposity and more atherogenic lipoproteins, independent of achieved BMI.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Aumento de Peso / Índice de Massa Corporal / Trajetória do Peso do Corpo Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Aumento de Peso / Índice de Massa Corporal / Trajetória do Peso do Corpo Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos