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Frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude.
Giraldo, Juan C; Acosta, Claudia; Giraldo-Grueso, Manuel.
Afiliação
  • Giraldo JC; Cardiothoracic Anesthesia Department, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.
  • Acosta C; Universidad del Rosario, Bogotá, Colombia.
  • Giraldo-Grueso M; Vascular Function Research Laboratory, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.
Med Gas Res ; 8(4): 150-153, 2018.
Article em En | MEDLINE | ID: mdl-30713667
This study reported the frequency of anesthetic overdose measured with the bispectral index in a high altitude city (Bogotá-Colombia, 2600 meters above sea level). We assembled a prospective cohort of patients. Preoperative variables were described, and 10 minutes after the surgical incision, bispectral index, mean alveolar concentration, mean arterial pressure, and oxygen saturation were recorded. Bispectral index was classified as superficial (60), adequate (40-60), and deep (> 40). Mean alveolar concentration was classified as low (< 0.8), normal (0.8-1.2), and high (> 1.2). We included 50 patients. The mean age of the patients was 36.3 ± 13.5 years; 48% were male and 78% were categorized as ASA I. Mean values of mean alveolar concentration and bispectral index were 1.14 ± 0.18 and 38.66 ± 6.9, respectively. Frequency of anesthetic overdose measured with bispectral index was 54% and only 20% with mean alveolar concentration. In total, 78% of patients received normal mean alveolar concentration values, and among these patients, 49% had deep bispectral index levels and 51% were adequate. There was no correlation between mean alveolar concentration and bispectral index (Pearson r = 0.161, P = 0.246) or between bispectral index and mean arterial pressure (Pearson r = 0.367, P = 0.08). All patients older than 60 years exhibited deep bispectral index levels, and although we did not identify a correlation between age and bispectral index, a tendency was observed (Pearson r = -0.087, P = 0.538). Safe and effective anesthesia overdose could be a common phenomenon. Bispectral index-guided anesthesia could be a helpful and reliable tool in the assessment and prevention of anesthesia overdose at high altitude. The study was approved by the ethics committee of the Fundación Cardioinfantil-Instituto de cardiología, Bogota, Colombia (approved number: 312017).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Aspecto: Ethics Idioma: En Revista: Med Gas Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Austrália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Aspecto: Ethics Idioma: En Revista: Med Gas Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Austrália