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Effects of Physical Rehabilitation in Patients with Spinocerebellar Ataxia Type 7.
Tercero-Pérez, Karla; Cortés, Hernán; Torres-Ramos, Yessica; Rodríguez-Labrada, Roberto; Cerecedo-Zapata, César M; Hernández-Hernández, Oscar; Pérez-González, Nelson; González-Piña, Rigoberto; Leyva-García, Norberto; Cisneros, Bulmaro; Velázquez-Pérez, Luis; Magaña, Jonathan J.
Afiliação
  • Tercero-Pérez K; Rehabilitation and Social Inclusion Center of Veracruz (CRIS-DIF), Xalapa, Veracruz, Mexico.
  • Cortés H; Laboratory of Genomic Medicine, Department of Genetics, National Rehabilitation Institute- Luis Guillermo Ibarra Ibarra (INR-LGII), México-Xochimilco No. 289, Col. Arenal Guadalupe, C.P, 14389, Ciudad de México (CDMX), Mexico.
  • Torres-Ramos Y; Department of Immunobiochemistry, National Perinatology Institute (INPer), Mexico City, Mexico.
  • Rodríguez-Labrada R; Center for Research and Rehabilitation of the Hereditary Ataxias (CIRAH), Carretera Central Km 5 ½ Reparto Edecío Pérez, 80100, Holguín, Cuba.
  • Cerecedo-Zapata CM; Rehabilitation and Social Inclusion Center of Veracruz (CRIS-DIF), Xalapa, Veracruz, Mexico.
  • Hernández-Hernández O; Laboratory of Genomic Medicine, Department of Genetics, National Rehabilitation Institute- Luis Guillermo Ibarra Ibarra (INR-LGII), México-Xochimilco No. 289, Col. Arenal Guadalupe, C.P, 14389, Ciudad de México (CDMX), Mexico.
  • Pérez-González N; Rehabilitation and Social Inclusion Center of Veracruz (CRIS-DIF), Xalapa, Veracruz, Mexico.
  • González-Piña R; Laboratory of Genomic Medicine, Department of Genetics, National Rehabilitation Institute- Luis Guillermo Ibarra Ibarra (INR-LGII), México-Xochimilco No. 289, Col. Arenal Guadalupe, C.P, 14389, Ciudad de México (CDMX), Mexico.
  • Leyva-García N; Laboratory of Genomic Medicine, Department of Genetics, National Rehabilitation Institute- Luis Guillermo Ibarra Ibarra (INR-LGII), México-Xochimilco No. 289, Col. Arenal Guadalupe, C.P, 14389, Ciudad de México (CDMX), Mexico.
  • Cisneros B; Department of Genetics and Molecular Biology, Center of Research and Advanced Studies (CINVESTAV-IPN), Mexico City, Mexico.
  • Velázquez-Pérez L; Center for Research and Rehabilitation of the Hereditary Ataxias (CIRAH), Carretera Central Km 5 ½ Reparto Edecío Pérez, 80100, Holguín, Cuba. velazq63@gmail.com.
  • Magaña JJ; Cuban Academy of Sciences, Havana, Cuba. velazq63@gmail.com.
Cerebellum ; 18(3): 397-405, 2019 Jun.
Article em En | MEDLINE | ID: mdl-30701400
Today, neurorehabilitation has become in a widely used therapeutic approach in spinocerebellar ataxias; however, there are scarce powerful clinical studies supporting this notion, and these studies require extension to other specific SCA subtypes in order to be able to form conclusions concerning its beneficial effects. Therefore, in this study, we perform for the first time a case-control pilot randomized, single-blinded, cross-sectional, and observational study to evaluate the effects of physical neurorehabilitation on the clinical and biochemical features of patients with spinocerebellar ataxia type 7 (SCA7) in 18 patients diagnosed with SCA7. In agreement with the exercise regimen, the participants were assigned to groups as follows: (a) the intensive training group, (b) the moderate training group, and (c) the non-training group (control group).We found that both moderate and intensive training groups showed a reduction in SARA scores but not INAS scores, compared with the control group (p < 0.05). Furthermore, trained patients exhibited improvement in the SARA sub-scores in stance, gait, dysarthria, dysmetria, and tremor, as compared with the control group (p < 0.05). No significant improvements were found in daily living activities, as revealed by Barthel and Lawton scales (p > 0.05). Patients under physical training exhibited significantly decreased levels in lipid-damage biomarkers and malondialdehyde, as well as a significant increase in the activity of the antioxidant enzyme PON-1, compared with the control group (p < 0.05). Physical exercise improved some cerebellar characteristics and the oxidative state of patients with SCA7, which suggest a beneficial effect on the general health condition of patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Modalidades de Fisioterapia / Ataxias Espinocerebelares Tipo de estudo: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cerebellum Assunto da revista: CEREBRO Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Modalidades de Fisioterapia / Ataxias Espinocerebelares Tipo de estudo: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cerebellum Assunto da revista: CEREBRO Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos