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The Impact of Variants in Genes Associated with Estradiol Synthesis on Hormone Levels and Oocyte Retrieval in Patients Who Underwent Controlled Ovarian Hyperstimulation.
Amaro, Aline; Polerá, Daniela; Figueiredo, Francisco Winter Dos Santos; Bianco, Bianca; Christofolini, Denise Maria; Barbosa, Caio Parente.
Afiliação
  • Amaro A; 1 Institute Ideia Fértil of Reproductive Health, Santo André, Brazil.
  • Polerá D; 1 Institute Ideia Fértil of Reproductive Health, Santo André, Brazil.
  • Figueiredo FWDS; 2 Collective Health Department, Reproductive Health and Population Genetics Discipline, Faculdade de Medicina do ABC, Santo André, Brazil.
  • Bianco B; 1 Institute Ideia Fértil of Reproductive Health, Santo André, Brazil.
  • Christofolini DM; 2 Collective Health Department, Reproductive Health and Population Genetics Discipline, Faculdade de Medicina do ABC, Santo André, Brazil.
  • Barbosa CP; 1 Institute Ideia Fértil of Reproductive Health, Santo André, Brazil.
Genet Test Mol Biomarkers ; 23(2): 145-149, 2019 Feb.
Article em En | MEDLINE | ID: mdl-30688541
AIMS: To correlate differences in estradiol levels in serum and follicular fluid with genetic variants and to determine if they play a role in the results following assisted reproductive technology (ART). PATIENTS AND METHODS: A cross-sectional study was developed at the Ideia Fértil Institute of Reproductive Health. Two hundred two female patients were selected and underwent controlled ovarian hyperstimulation cycles. Patients for this study were chosen based on their male partners' infertility. Genotypes of selected variants of CYP19A1, CYP17A1, HSD17, and COMT were compared to the estradiol measurements from follicular fluid and serum, as well as to the number and maturation status of the oocytes retrieved. RESULTS: Patients with the variant homozygous genotype AA of CYP19A1 (rs10046) showed increased serum concentrations of estradiol when compared to patients with other genotypes (p = 0.005). The same polymorphism effect was not observed in follicular fluid. This CYP19A1 variant did not affect the number of oocytes recovered nor their maturation level. CONCLUSION: The CYP19A1 variant is associated with an estradiol imbalance in serum. Other pathways, however, may contribute to the formation of the final estradiol metabolite in follicular fluid as well as its impact on the oocyte maturation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aromatase / Estradiol Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Revista: Genet Test Mol Biomarkers Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aromatase / Estradiol Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Revista: Genet Test Mol Biomarkers Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos