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Width of sulcus and thickness of gyrus in patients with cerebral atherosclerosis: a new tool for the prevention of vascular cognitive impairment.
Ramalho, Luciana Santos; Silveira, Luciano Alves Matias da; Fonseca, Bárbara Cecílio; Félix, José Eduardo Reis; Morais, Lourimar José; Soares, Maria Helena; Ferraz, Mara Lúcia Fonseca; Teixeira, Vicente de Paula Antunes; Pereira, Sanívia Aparecida Lima.
Afiliação
  • Ramalho LS; . PhD in Pathology, Student of Postgraduate Course Health Sciences, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba (MG), Brasil.
  • Silveira LAMD; . MS in Pathology, Anesthesiologist, Professor of Anesthesiology, Department of Surgery, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba (MG), Brasil.
  • Fonseca BC; . Medical Student at UFTM, Scientific Initiation Grant from UFTM (BIC/Fapemig), Uberaba (MG), Brasil.
  • Félix JER; . Department of Radiology, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba (MG), Brasil.
  • Morais LJ; . MS in Pathology, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba (MG), Brasil.
  • Soares MH; . MS in Pathology, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba (MG), Brasil.
  • Ferraz MLF; . PhD in Pathology, Professor of Postgraduate Course Health Sciences, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba (MG), Brasil.
  • Teixeira VPA; . Pathologist, Professor of General Pathology, Institute of Biological and Natural Sciences, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba (MG), Brasil.
  • Pereira SAL; . PhD in Pathology, Professor of Postgraduate Course Health Sciences, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba (MG), Brasil.
Rev Assoc Med Bras (1992) ; 64(8): 684-691, 2018 Aug.
Article em En | MEDLINE | ID: mdl-30673038
BACKGROUND AND PURPOSE: Cerebral atherosclerosis is the main cause of lesions that contribute to vascular cognitive impairment and vascular dementia, followed by arteriosclerosis of small vessels and cerebral amyloid angiopathy. The purpose of this study was to compare the post-mortem radiological alterations of autopsied adults with the macroscopic alterations in the posterior region of these brains in order to establish a relationship between the two forms of analysis and to discuss the relevance of the prevention of vascular cognitive impairment in patients with encephalic atherosclerosis. MATERIALS AND METHODS: Thirteen brains were analysed macroscopically to assess the degree of atherosclerosis of the basilar and the posterior cerebral arteries. The patients were autopsied in the Subject of General Pathology at General Hospital of Triângulo Mineiro Federal University in Uberaba, state of Minas Gerais, Brazil. The qualitative analysis of atherosclerosis was performed with classification into mild, moderate or severe. In the posterior region of the brains, width of sulcus and thickness of gyrus were measured by macroscopic analysis and by tomographic analysis. RESULTS AND CONCLUSIONS: There was a decrease in calcarine sulcus width and an increase in medial temporal occipital gyrus thickness in patients with a higher degree of atherosclerosis, macroscopically and in tomography, respectively. Low oxygenation caused by atherosclerosis probably leads to an encephalic parenchyma inflammation that causes microglial cells hypertrophy provoking increase in the gyrus thickness and decrease in the sulcus width, as observed in the present study.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lobo Temporal / Demência Vascular / Arteriosclerose Intracraniana / Disfunção Cognitiva / Lobo Occipital Tipo de estudo: Etiology_studies / Qualitative_research Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lobo Temporal / Demência Vascular / Arteriosclerose Intracraniana / Disfunção Cognitiva / Lobo Occipital Tipo de estudo: Etiology_studies / Qualitative_research Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil