Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

Kilpeläinen, Tuomas O; Bentley, Amy R; Noordam, Raymond; Sung, Yun Ju; Schwander, Karen; Winkler, Thomas W; Jakupovic, Hermina; Chasman, Daniel I; Manning, Alisa; Ntalla, Ioanna; Aschard, Hugues; Brown, Michael R; de Las Fuentes, Lisa; Franceschini, Nora; Guo, Xiuqing; Vojinovic, Dina; Aslibekyan, Stella; Feitosa, Mary F; Kho, Minjung; Musani, Solomon K; Richard, Melissa; Wang, Heming; Wang, Zhe; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Dorajoo, Rajkumar; Fisher, Virginia; Hartwig, Fernando P; Horimoto, Andrea R V R; Li, Changwei; Lohman, Kurt K; Marten, Jonathan; Sim, Xueling; Smith, Albert V; Tajuddin, Salman M; Alver, Maris; Amini, Marzyeh; Boissel, Mathilde; Chai, Jin Fang; Chen, Xu; Divers, Jasmin; Evangelou, Evangelos; Gao, Chuan; Graff, Mariaelisa; Harris, Sarah E; He, Meian; Hsu, Fang-Chi; Jackson, Anne U; Zhao, Jing Hua

Kilpeläinen, Tuomas O; Bentley, Amy R; Noordam, Raymond; Sung, Yun Ju; Schwander, Karen; Winkler, Thomas W; Jakupovic, Hermina; Chasman, Daniel I; Manning, Alisa; Ntalla, Ioanna; Aschard, Hugues; Brown, Michael R; de Las Fuentes, Lisa; Franceschini, Nora; Guo, Xiuqing; Vojinovic, Dina; Aslibekyan, Stella; Feitosa, Mary F; Kho, Minjung; Musani, Solomon K; Richard, Melissa; Wang, Heming; Wang, Zhe; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Dorajoo, Rajkumar; Fisher, Virginia; Hartwig, Fernando P; Horimoto, Andrea R V R; Li, Changwei; Lohman, Kurt K; Marten, Jonathan; Sim, Xueling; Smith, Albert V; Tajuddin, Salman M; Alver, Maris; Amini, Marzyeh; Boissel, Mathilde; Chai, Jin Fang; Chen, Xu; Divers, Jasmin; Evangelou, Evangelos; Gao, Chuan; Graff, Mariaelisa; Harris, Sarah E; He, Meian; Hsu, Fang-Chi; Jackson, Anne U; Zhao, Jing Hua.

Afiliação

Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark. tuomas.kilpelainen@sund.ku.dk.
Bentley AR; Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA. tuomas.kilpelainen@sund.ku.dk.
Noordam R; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
Sung YJ; Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Schwander K; Division of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA.
Winkler TW; Division of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA.
Jakupovic H; Department of Genetic Epidemiology, University of Regensburg, Regensburg, 93051, Germany.
Chasman DI; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Manning A; Preventive Medicine, Brigham and Women's Hospital, Boston, 02215, MA, USA.
Ntalla I; Harvard Medical School, Boston, 02131, MA, USA.
Aschard H; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, 02114, MA, USA.
Brown MR; Department of Medicine, Harvard Medical School, Boston, 02115, MA, USA.
de Las Fuentes L; Clinical Pharmacology, William Harvey Research Instititute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Franceschini N; Department of Epidemiology, Harvard School of Public Health, Boston, 02115, MA, USA.
Guo X; Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, 75015, France.
Vojinovic D; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Aslibekyan S; Division of Biostatistics, Washington University School of Medicine, St. Louis, 63110, MO, USA.
Feitosa MF; Cardiovascular Division, Department of Medicine, Washington University, St. Louis, 63110, MO, USA.
Kho M; Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, 27514, NC, USA.
Musani SK; The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, 90502, CA, USA.
Richard M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
Wang H; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, 35294, AL, USA.
Wang Z; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, 63108, MO, USA.
Bartz TM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
Bielak LF; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, 39213, MS, USA.
Campbell A; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Dorajoo R; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, 02115, MA, USA.
Fisher V; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Hartwig FP; Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, 98101, WA, USA.
Horimoto ARVR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.
Li C; Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Lohman KK; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, 138672, Singapore.
Marten J; Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.
Sim X; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, 96020220, RS, Brazil.
Smith AV; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK.
Tajuddin SM; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, 01246903, SP, Brazil.
Alver M; Epidemiology and Biostatistics, University of Giorgia at Athens College of Public Health, Athens, 30602, GA, USA.
Amini M; Public Health Sciences, Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, 27157, NC, USA.
Boissel M; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Chai JF; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
Chen X; Icelandic Heart Association, 201, Kopavogur, Iceland.
Divers J; Department of Biostatistics, University of Michigan, Ann Arbor, 48109, MI, USA.
Evangelou E; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, 21224, MD, USA.
Gao C; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Graff M; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
Harris SE; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, 59000, France.
He M; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.
Hsu FC; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, Sweden.
Jackson AU; Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, 27157, NC, USA.
Zhao JH; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.

Nat Commun ; 10(1): 376, 2019 01 22.

Article em En | MEDLINE | ID: mdl-30670697

Assuntos

Exercício Físico; Loci Gênicos/genética; Lipídeos/sangue; Lipídeos/genética; Adolescente; Adulto; Idoso; Idoso de 80 Anos ou mais; Povo Asiático/genética; População Negra/genética; Brasil; Proteínas de Ligação ao Cálcio/genética; Colesterol/sangue; HDL-Colesterol/sangue; HDL-Colesterol/genética; LDL-Colesterol/sangue; LDL-Colesterol/genética; Feminino; Estudo de Associação Genômica Ampla; Genótipo; Hispânico ou Latino/genética; Humanos; Proteínas com Homeodomínio LIM/genética; Metabolismo dos Lipídeos/genética; Masculino; Proteínas de Membrana/genética; Proteínas Associadas aos Microtúbulos/genética; Pessoa de Meia-Idade; Proteínas Musculares/genética; Proteínas do Tecido Nervoso/genética; Fatores de Transcrição/genética; Triglicerídeos/sangue; Triglicerídeos/genética; População Branca/genética; Adulto Jovem

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Loci Gênicos / Lipídeos Tipo de estudo: Prognostic_studies Limite: Aged80 País/Região como assunto: America do sul / Brasil Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Dinamarca País de publicação: Reino Unido

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