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Global cognitive performance is associated with sleep efficiency measured by polysomnography in patients with Parkinson's disease.
Sobreira, Emmanuelle S T; Sobreira-Neto, Manoel A; Pena-Pereira, Márcio A; Chagas, Marcos H N; Fernandes, Regina M F; Eckeli, Alan L; Tumas, Vitor.
Afiliação
  • Sobreira EST; Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
  • Sobreira-Neto MA; Unichristus University, Fortaleza, Brazil.
  • Pena-Pereira MA; Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
  • Chagas MHN; Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
  • Fernandes RMF; Department of Gerontology, Federal University of São Carlos, São Carlos, Brazil.
  • Eckeli AL; Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
  • Tumas V; Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Psychiatry Clin Neurosci ; 73(5): 248-253, 2019 May.
Article em En | MEDLINE | ID: mdl-30636105
AIM: Sleep disorders can be associated with an increased risk for cognitive decline in patients with Parkinson's disease (PD). The aim of this study was to examine the association between cognitive status and presence of sleep symptoms and sleep disorders in PD patients. METHODS: We evaluated excessive sleepiness, other sleep symptoms, and performed polysomnography and neuropsychological evaluation in 79 patients. They were classified as having normal cognition (PDNC), mild cognitive impairment (PDMCI), or dementia (PDD). RESULTS: There were 29 PDNC, 39 PDMCI, and 11 PDD patients. PDD patients were older, had higher scores on the Unified Parkinson's Disease Rating Scale, and lower Schwab and England Activities of Daily Living scores than PDNC patients. After analysis of the polysomnographic variables, it was also found that PDD patients had a lower sleep efficiency, lower total sleep time, and lower number of sleep state changes than PDNC patients. In a stepwise analysis, defining Mattis Dementia Rating Scale scores as the dependent variable, the results were a model that selected three variables that accounted for 59% of the variation in the Mattis Dementia Rating Scale score: wake time after sleep onset, number of state changes, and schooling. CONCLUSION: We found a significant association between global cognitive performance and wake time after sleep onset and the number of state changes during sleep measured in the polysomnography of PD patients. However, we did not find any other association between sleep disorders or symptoms and cognitive status or cognitive performance of PD patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Transtornos do Sono-Vigília / Demência / Disfunção Cognitiva Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Clin Neurosci Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Austrália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Transtornos do Sono-Vigília / Demência / Disfunção Cognitiva Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Clin Neurosci Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Austrália