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Fine-scale spatial and temporal dynamics of kdr haplotypes in Aedes aegypti from Mexico.
Grossman, Marissa K; Rodriguez, Julian; Barreiro, Anuar Medina; Lenhart, Audrey; Manrique-Saide, Pablo; Vazquez-Prokopec, Gonzalo M.
Afiliação
  • Grossman MK; Department of Entomology, Pennsylvania State University, University Park, PA, USA. mzg175@psu.edu.
  • Rodriguez J; Department of Environmental Sciences, Emory University, Atlanta, GA, USA.
  • Barreiro AM; Departamento de Zoología, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.
  • Lenhart A; Center for Global Health/Division of Parasitic Diseases and Malaria/Entomology Branch, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Manrique-Saide P; Departamento de Zoología, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.
  • Vazquez-Prokopec GM; Department of Environmental Sciences, Emory University, Atlanta, GA, USA.
Parasit Vectors ; 12(1): 20, 2019 Jan 09.
Article em En | MEDLINE | ID: mdl-30626410
BACKGROUND: As resistance to insecticides increases in disease vectors, it has become exceedingly important to monitor populations for susceptibility. Most studies of field populations of Aedes aegypti have largely characterized resistance patterns at the spatial scale of the city or country, which may not be completely informative given that insecticide application occurs at the scale of the house or city block. Phenotypic resistance to pyrethroids dominates in Ae. aegypti, and it has been partially explained by mutations in the voltage-gated sodium channel gene. Here, we assess community-level patterns of four knockdown resistance (kdr) haplotypes (C1534/I1016, F1534/I1016, C1534/V1016 and F1534/V1016) in Ae. aegypti in 24 randomly chosen city blocks from a city in Yucatán State, Mexico, during both the dry and wet season and over two years. RESULTS: Three of the four haplotypes, C1534/I1016, C1534/V1016 and F1534/V1016 were heterogeneous between city blocks at all four sampling time points, and the double mutant haplotype, C1534/I1016, showed a significant increase following the wet season. The F1534/I1016 haplotype was rarely detected, similar to other studies. However, when haplotype frequencies were aggregated to a coarser spatial scale, the differences in space and time were obscured. CONCLUSIONS: Our results provide empirical evidence that the selection of kdr alleles is occurring at fine spatial scales, indicating that future studies should include this scale to better understand evolutionary processes of resistance in natural populations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Haplótipos / Resistência a Inseticidas / Aedes / Mosquitos Vetores Limite: Animals País/Região como assunto: Mexico Idioma: En Revista: Parasit Vectors Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Haplótipos / Resistência a Inseticidas / Aedes / Mosquitos Vetores Limite: Animals País/Região como assunto: Mexico Idioma: En Revista: Parasit Vectors Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido