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Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia.
Ryan, Rita M; Feng, Rui; Bazacliu, Catalina; Ferkol, Thomas W; Ren, Clement L; Mariani, Thomas J; Poindexter, Brenda B; Wang, Fan; Moore, Paul E.
Afiliação
  • Ryan RM; Department of Pediatrics, Medical University of South Carolina, Charleston, SC. Electronic address: ryanr@musc.edu.
  • Feng R; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA.
  • Bazacliu C; Department of Pediatrics, University of Florida, Gainesville, FL.
  • Ferkol TW; Department of Pediatrics, Washington University, St. Louis, MO.
  • Ren CL; Division of Pediatric Pulmonology, Allergy and Sleep Medicine, Department of Pediatrics, Indiana University, Indianapolis, IN.
  • Mariani TJ; Department of Pediatrics, University of Rochester, Rochester, NY.
  • Poindexter BB; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
  • Wang F; Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH.
  • Moore PE; Department of Pediatrics, Vanderbilt University, Nashville, TN.
J Pediatr ; 207: 130-135.e2, 2019 04.
Article em En | MEDLINE | ID: mdl-30612812
OBJECTIVE: To use a large current prospective cohort of infants <29 weeks to compare bronchopulmonary dysplasia (BPD) rates in black and white infants. STUDY DESIGN: The Prematurity and Respiratory Outcome Program (PROP) enrolled 835 infants born in 2011-2013 at <29 weeks of gestation; 728 black or white infants survived to 36 weeks postmenstrual age (PMA). Logistic regression was used to compare BPD outcomes (defined as supplemental oxygen requirement at 36 weeks PMA) between the races, adjusted for gestational age (GA), antenatal steroid use, intubation at birth, and surfactant use at birth. RESULTS: Of 707 black or white infants with available BPD outcomes, BPD was lower in black infants (38% vs 45%), even though they were of significantly lower GA. At every GA, BPD was more common in white infants. The aOR for BPD was 0.60 (95% CI, 0.42-0.85; P = .004) for black infants compared with white infants after adjusting for GA. Despite the lower rate of BPD, black infants had a higher rate of first-year post-prematurity respiratory disease (black, 79%; white, 63%). CONCLUSIONS: In this large cohort of recently born preterm infants at <29 weeks GA, compared with white infants, black infants had a lower risk of BPD but an increased risk of persistent respiratory morbidity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Negro ou Afro-Americano / Displasia Broncopulmonar / Recém-Nascido Prematuro / Unidades de Terapia Intensiva Neonatal / Medição de Risco / Hospitalização Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Negro ou Afro-Americano / Displasia Broncopulmonar / Recém-Nascido Prematuro / Unidades de Terapia Intensiva Neonatal / Medição de Risco / Hospitalização Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos