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Serum advanced glycation end products are not associated with muscle strength in hemodialysis patients.
Silva, Debora M; Queiroz, Nayara P; Freitas, Ana Tereza V S; Passarelli, Marisa; Corgosinho, Flávia Campos; Peixoto, Maria do Rosário G.
Afiliação
  • Silva DM; Graduate Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goias, Goiania, Brazil.
  • Queiroz NP; Graduate Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goias, Goiania, Brazil.
  • Freitas ATVS; Graduate Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goias, Goiania, Brazil.
  • Passarelli M; Laboratório de Lipides (LIM 10), Hospital das Clinicas (HCFMUSP) da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, SP, Brazil.
  • Peixoto MDRG; Graduate Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goias, Goiania, Brazil. mrg.peixoto@uol.com.br.
Eur J Clin Nutr ; 73(4): 617-623, 2019 04.
Article em En | MEDLINE | ID: mdl-30607008
BACKGROUND: Advanced glycation end products (AGEs) are elevated in patients with renal failure and may potentially affect skeletal muscle. The aim of this study was to evaluate whether serum concentrations of AGEs are associated with muscle strength in hemodialysis (HD) patients, since this association is not clear in the literature. METHODS: This research has a cross-sectional design and included 96 patients on hemodialysis treatment (20-69 years). Serum AGEs (ELISA), three-day dietary records, anthropometric and bioimpedance variables and handgrip strength (HGS) were analysed. Serum AGEs were analyzed by ELISA test. RESULTS: Men's HGS were significantly higher than women's (p < 0.001). Serum AGEs of the individuals of the highest HGS quartile versus the lowest quartile were 11.27 ± 2.52 and 9.06 ± 2.14 (µg/mL), respectively (p = 0.02). After adjustment for potential confounders, the correlation between serum AGEs and HGS lost statistical significance. The main factors that were associated to muscle strength were aging, BMI, percentage of fat-free mass and serum albumin. CONCLUSION: Contrary to our hypothesis, serum AGEs were not associated with muscular strength in HD patients. These results suggest that serum AGE is not a good indicator of muscle strength in this population and others factors related to the disease may be more important and significant in reducing muscle strength than the serum concentrations of AGEs alone.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diálise Renal / Produtos Finais de Glicação Avançada / Insuficiência Renal / Força Muscular Tipo de estudo: Evaluation_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Clin Nutr Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diálise Renal / Produtos Finais de Glicação Avançada / Insuficiência Renal / Força Muscular Tipo de estudo: Evaluation_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Clin Nutr Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido