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A hemodynamic network involving the insula, the cingulate, and the basal forebrain correlates with EEG synchronization phases of sleep instability.
Kokkinos, Vasileios; Vulliémoz, Serge; Koupparis, Andreas M; Koutroumanidis, Michalis; Kostopoulos, George K; Lemieux, Louis; Garganis, Kyriakos.
Afiliação
  • Kokkinos V; Department of Neurological Surgery, School of Medicine, University of Pittsburgh, PA.
  • Vulliémoz S; Epilepsy Center of Thessaloniki, St. Luke's Hospital, Thessaloniki, Greece.
  • Koupparis AM; Neurophysiology Unit, Department of Physiology, Medical School, University of Patras, Greece.
  • Koutroumanidis M; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, UK.
  • Kostopoulos GK; MRI Unit, Epilepsy Society, Chalfont St. Peter, UK.
  • Lemieux L; EEG and Epilepsy Unit, Neurology, University Hospital and Faculty of Medicine, Geneva, Switzerland.
  • Garganis K; Neurophysiology Unit, Department of Physiology, Medical School, University of Patras, Greece.
Sleep ; 42(4)2019 04 01.
Article em En | MEDLINE | ID: mdl-30566659
The cyclic alternating pattern (CAP) encompasses the pseudoperiodic appearance of synchronized brain waves and rhythms and is considered a regulator of the nonrapid eye movement (NREM) sleep vigilance level, reflecting sleep instability. To determine the brain regions responsible for this phenomenon, we scored and analyzed sleep functional magnetic resonance imaging data acquired with simultaneous electroencephalography (EEG-fMRI). Group analysis revealed a set of brain areas showing statistically significant blood oxygen-level dependent signal correlated positively with the synchronization phase of the CAP, most prominent being the insula, the middle cingulate gyrus, and the basal forebrain. These areas may form a network acting as a synchronization pacemaker, controlling the level of NREM sleep vigilance and the sleeper's arousability.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Fases do Sono / Ondas Encefálicas / Prosencéfalo Basal Limite: Adult / Female / Humans / Male Idioma: En Revista: Sleep Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Fases do Sono / Ondas Encefálicas / Prosencéfalo Basal Limite: Adult / Female / Humans / Male Idioma: En Revista: Sleep Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos