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Plasma and erythrocyte ω-3 and ω-6 fatty acids are associated with multiple inflammatory and oxidative stress biomarkers in breast cancer.
Lira, Leticia Gomes; Justa, Rute Mattos Dourado Esteves; Carioca, Antonio Augusto Ferreira; Verde, Sara Maria Moreira Lima; Sampaio, Geni Rodrigues; Torres, Elizabeth Aparecida Ferraz da Silva; Damasceno, Nágila Raquel Teixeira.
Afiliação
  • Lira LG; Nutrition Course, University of Fortaleza (UNIFOR), Fortaleza, Brazil.
  • Justa RMDE; Nutrition Course, University of Fortaleza (UNIFOR), Fortaleza, Brazil.
  • Carioca AAF; Nutrition Course, University of Fortaleza (UNIFOR), Fortaleza, Brazil; Nutrition Department, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil.
  • Verde SMML; Nutrition Course, Universidade Estadual do Ceará, Fortaleza, Brazil.
  • Sampaio GR; Nutrition Department, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil.
  • Torres EAFDS; Nutrition Department, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil.
  • Damasceno NRT; Nutrition Department, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil. Electronic address: Nagila@usp.br.
Nutrition ; 58: 194-200, 2019 02.
Article em En | MEDLINE | ID: mdl-30553106
OBJECTIVES: The aim of this study was to assess the association of plasma and erythrocyte ω-3 and ω-6 fatty acids with multiple oxidative stress biomarkers in breast cancer patients. METHODS: Ninety-five women with recently diagnosed breast cancer and no previous treatment were selected for this study. The socioeconomic, clinical, and demographic profile of the patients was determined using a structured questionnaire and medical records. Body weight and height were measured to calculate body mass index. Blood samples were drawn after a 12-h fast for biochemical analyses. The oxidative stress biomarkers low-density lipoprotein (-) and its anti-low-density lipoprotein (-) antibodies, α-tocopherol, ß-carotene, high-density lipoprotein cholesterol, thiobarbituric acid reactive substance, and adiponectin were measured. Plasma and erythrocyte fatty acids were assessed by gas chromatography. Factor and principal component analysis was used to identify three factors called factor 1 (anti-inflammatory), factor 2 (antioxidant), and factor 3 (oxidant). Linear regression, adjusted for confounding variables, was used to estimate the association of these factors with plasma and erythrocyte ω-3 and ω-6 fatty acids and their ratios. RESULTS: ω-3 series fatty acids showed a positive association with Factor 1. A positive association of plasma and erythrocyte ω-6 fatty acids with factors 1 and 2, respectively, was found. ω-6/ω-3 ratio (plasma) was inversely associated with the anti-inflammatory factor. CONCLUSION: Polyunsaturated fatty acids of the plasma and erythrocyte ω-3 and ω-6 series were associated with multiple inflammatory and oxidative stress biomarkers in breast cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Ácidos Graxos Ômega-3 / Estresse Oxidativo / Ácidos Graxos Ômega-6 / Inflamação Tipo de estudo: Prognostic_studies / Qualitative_research / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Nutrition Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Ácidos Graxos Ômega-3 / Estresse Oxidativo / Ácidos Graxos Ômega-6 / Inflamação Tipo de estudo: Prognostic_studies / Qualitative_research / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Nutrition Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos