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Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine.
Moya, Iván M; Halder, Georg.
Afiliação
  • Moya IM; Facultad de Ingeniería y Ciencias Aplicadas, Universidad de Las Americas, Quito, Ecuador. ivan.moya.molina@udla.edu.ec.
  • Halder G; VIB Center for Cancer Biology, and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium. ivan.moya.molina@udla.edu.ec.
Nat Rev Mol Cell Biol ; 20(4): 211-226, 2019 04.
Article em En | MEDLINE | ID: mdl-30546055
The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), regulate organ growth and cell plasticity during animal development and regeneration. Remarkably, experimental activation of YAP/TAZ in the mouse can promote regeneration in organs with poor or compromised regenerative capacity, such as the adult heart and the liver and intestine of old or diseased mice. However, therapeutic YAP/TAZ activation may cause serious side effects. Most notably, YAP/TAZ are hyperactivated in human cancers, and prolonged activation of YAP/TAZ triggers cancer development in mice. Thus, can the power of YAP/TAZ to promote regeneration be harnessed in a safe way? Here, we review the role of Hippo signalling in animal regeneration, examine the promises and risks of YAP/TAZ activation for regenerative medicine and discuss strategies to activate YAP/TAZ for regenerative therapy while minimizing adverse side effects.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Transdução de Sinais / Proteínas Serina-Treonina Quinases / Proteínas Adaptadoras de Transdução de Sinal Limite: Animals / Humans Idioma: En Revista: Nat Rev Mol Cell Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Equador País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Transdução de Sinais / Proteínas Serina-Treonina Quinases / Proteínas Adaptadoras de Transdução de Sinal Limite: Animals / Humans Idioma: En Revista: Nat Rev Mol Cell Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Equador País de publicação: Reino Unido