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Immune response to purified protein derivative in infants from helminth-sensitized mothers - A cases series.
de Souza Fernandes, Erica; Correia do Nascimento, Wheverton Ricardo; Alves Dos Santos, Patrícia; de Oliveira Nóbrega, Cassia Gisele; Barros Lorena, Virginia; Simões Barbosa, Constança; Medeiros, Décio; Wanick Sarinho, Silvia; Assis Costa, Vlaudia Maria; Oliveira de Souza, Valdênia Maria.
Afiliação
  • de Souza Fernandes E; Immunology Section, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Brazil.
  • Correia do Nascimento WR; Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
  • Alves Dos Santos P; Immunology Section, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Brazil.
  • de Oliveira Nóbrega CG; Immunology Section, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Brazil.
  • Barros Lorena V; Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
  • Simões Barbosa C; Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
  • Medeiros D; Research Center for Allergy and Clinical Immunology, Federal University of Pernambuco, Recife, Brazil.
  • Wanick Sarinho S; Department of Maternal and Infant, Federal University of Pernambuco, Recife, Brazil.
  • Assis Costa VM; Immunology Section, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Brazil; Department of Tropical Medicine, Federal University of Pernambuco, Recife, Brazil.
  • Oliveira de Souza VM; Immunology Section, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Brazil; Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Pernambuco, Recife, Brazil. Electronic address: valdenia.souza@gmail.com.
J Microbiol Immunol Infect ; 53(4): 634-639, 2020 Aug.
Article em En | MEDLINE | ID: mdl-30522970
BACKGROUND: Maternal exposure to antibodies, cytokines or parasitic antigens during gestation may alter the degree of immune competence of offspring. Here we describe the production of cytokines and chemokines, and the ability to activation of the immune response in infants from mothers sensitized to helminths. METHODS: It were selected five infants born to helminth-seropositive mothers but who were negative for current helminth infection. Whole blood was cultured without stimulus, with phytohemagglutinin mitogen (5 µg/ml, 24 h) or with purified protein derivative (PPD) (1 µg/ml, 24 h), and the supernatant was assessed for presence of Th1/Th2 cytokines (IFN-γ, TNF-α, IL-10, IL-5, IL-4 and IL-2) and chemokines (CXCL10, CCL2, CXCL9, CCL5 and CXCL8) by cytometric bead array. RESULTS: All infants produced CCL5. Two infants demonstrated a mixed profile of Th1 (CXCL9) and Th2 (CCL2) chemokines in the presence of CXCL10, while one infant showed skewing towards Th2 without CXCL10 and two of them had been impaired immune response (children from sensitized to Schistosoma mansoni mothers). CONCLUSION: Infants with Th1 and Th2 profile chemokines demonstrated a good response to vaccination, indicated by CXCL10 levels, but not infants predominantly Th2-skewed profile. These results highlight that children from mothers sensitized to S. mansoni may lead to ineffective immune response to PPD, while mothers sensitized to Ascaris lumbricoides showed no such impairment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas / Quimiocinas / Imunidade / Antígenos de Helmintos Tipo de estudo: Observational_studies Limite: Adult / Animals / Female / Humans / Infant / Pregnancy Idioma: En Revista: J Microbiol Immunol Infect Assunto da revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas / Quimiocinas / Imunidade / Antígenos de Helmintos Tipo de estudo: Observational_studies Limite: Adult / Animals / Female / Humans / Infant / Pregnancy Idioma: En Revista: J Microbiol Immunol Infect Assunto da revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido