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Association between exhaled carbon monoxide and asthma outcomes in Peruvian children.
Pereira, Amanda A; Pollard, Suzanne L; Locke, Robert; Romero, Karina; Lima, John J; Hansel, Nadia N; Checkley, William.
Afiliação
  • Pereira AA; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA.
  • Pollard SL; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA; Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, USA.
  • Locke R; Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, USA.
  • Romero K; Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, USA.
  • Lima JJ; Center for Pharmacogenomics and Translational Research, Nemours Children's Health System, Jacksonville, USA.
  • Hansel NN; Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, USA.
  • Checkley W; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA; Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, USA; Biomedical Research Unit, A.B. PRISMA, Lima, Peru. Electronic address: wcheckl1@jhmi
Respir Med ; 145: 212-216, 2018 12.
Article em En | MEDLINE | ID: mdl-30509712
BACKGROUND: Asthma prevalence continues to increase in low and middle-income countries, presenting challenges in assessing asthma control in resource-poor settings. Previous studies suggest that exhaled carbon monoxide (eCO) is higher with asthma severity and lower with treatment. We hypothesized that eCO levels may be elevated in children with asthma, particularly in children with partially controlled or uncontrolled asthma in a low-resource setting in Lima, Peru. METHODS: We compared average eCO levels between 248 children with asthma and 221 healthy controls as well as the odds of asthma by eCO quartiles (0-1, 2, 3, and ≥4 ppm) using multivariable linear and logistic regression. eCO quartiles were also used to compare the odds of partially controlled or uncontrolled asthma (score ≤19 on the Asthma Control Test) in a multivariable logistic regression model. FINDINGS: Average adjusted eCO level was 0.56 ppm (95% CI 0.07-1.05) higher in children with asthma. The adjusted odds of asthma were 1.22 (95% CI 0.75-1.97), 1.46 (0.81-2.63), and 1.76 (0.96-3.23) in the second, third, and fourth eCO quartiles compared to the first eCO quartile, respectively. Among children with asthma, the adjusted odds of partially controlled or uncontrolled asthma in those in the second, third, and fourth eCO quartiles, compared to the first, were 1.61 (95% CI 0.74-3.48), 3.66 (95% CI 1.51-8.87), and 2.50 (95% CI 1.06-5.90), respectively. INTERPRETATION: eCO may serve as an inexpensive biomarker for asthma control, particularly in low-resource settings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Testes Respiratórios / Monóxido de Carbono Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: America do sul / Peru Idioma: En Revista: Respir Med Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Testes Respiratórios / Monóxido de Carbono Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: America do sul / Peru Idioma: En Revista: Respir Med Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido