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The association between dengue immunoglobulin G titres with previous clinical dengue infection and white cell counts in Cuban children: A population-based study.
Suárez-Medina, Ramón; Venero-Fernández, Silvia Josefina; Batista-Gutierrez, Lourdes; Estrada-Rondon, Yanelis de Los Angeles; Alfonso-Hernandez, Anadelis; Casanave-Guarnaluce, Dulcima; Sardinas-Baez, Nieves; Castillo-Aguilar, Ivette; Febles-Del Toro, Jorge Antonio; Fogarty, Andrew W.
Afiliação
  • Suárez-Medina R; Instituto Nacional de Higiene, Epidemiología y Microbiología, Infanta No 1158 e/ Llinás y Clavel, Código Postal, La Habana, Cuba.
  • Venero-Fernández SJ; Instituto Nacional de Higiene, Epidemiología y Microbiología, Infanta No 1158 e/ Llinás y Clavel, Código Postal, La Habana, Cuba.
  • Batista-Gutierrez L; Instituto Nacional de Higiene, Epidemiología y Microbiología, Infanta No 1158 e/ Llinás y Clavel, Código Postal, La Habana, Cuba.
  • Estrada-Rondon YLA; Dirección Municipal de Salud Pública municipios Cerro y Arroyo Naranjo, La Habana, Cuba.
  • Alfonso-Hernandez A; Dirección Municipal de Salud Pública municipios Cerro y Arroyo Naranjo, La Habana, Cuba.
  • Casanave-Guarnaluce D; Dirección Municipal de Salud Pública municipios Cerro y Arroyo Naranjo, La Habana, Cuba.
  • Sardinas-Baez N; Dirección Municipal de Salud Pública municipios Cerro y Arroyo Naranjo, La Habana, Cuba.
  • Castillo-Aguilar I; Dirección Municipal de Salud Pública municipios Cerro y Arroyo Naranjo, La Habana, Cuba.
  • Febles-Del Toro JA; Dirección Municipal de Salud Pública municipios Cerro y Arroyo Naranjo, La Habana, Cuba.
  • Fogarty AW; Nottingham NIHR Biomedical Research Unit, Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, United Kingdom.
PLoS One ; 13(11): e0207391, 2018.
Article em En | MEDLINE | ID: mdl-30485325
BACKGROUND: The prevalence of dengue infection is increasing globally. There are few prospective population-based surveillance studies of the immunological and inflammatory consequences of exposure to dengue virus in young children. OBJECTIVE: To study the association between serologically confirmed prior medical diagnosis of dengue infection and blood measures of systemic inflammation with dengue virus immunoglobulin G levels. METHODS: A population-based study of healthy three-year old children living in Havana, Cuba. RESULTS: 865 individuals provided a blood sample. Fourteen (1.6%) had a prior medical diagnosis of dengue infection, and 851 individuals had no prior medical diagnosis. There was no difference in the serum immunoglobulin G titres between these groups (Mann-Whitney test, p = 0.49). Total white cell count, blood neutrophil and eosinophil counts were linearly associated with a dengue immunoglobulin G value above the median value. CONCLUSIONS: There was no difference between the dengue immunoglobulin G titres in young children who had previously had clinically proven dengue infection compared to those who had no diagnosis of prior infection. This may be a consequence of a relatively high prevalence of sub-clinical infection. A higher dengue immunoglobulin G level was positively associated with a range of inflammatory biomarkers, although these data cannot demonstrate a causal association.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Dengue / Anticorpos Antivirais Tipo de estudo: Clinical_trials / Diagnostic_studies / Prevalence_studies Limite: Child, preschool / Female / Humans / Infant / Male País/Região como assunto: Caribe / Cuba Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Cuba País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Dengue / Anticorpos Antivirais Tipo de estudo: Clinical_trials / Diagnostic_studies / Prevalence_studies Limite: Child, preschool / Female / Humans / Infant / Male País/Região como assunto: Caribe / Cuba Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Cuba País de publicação: Estados Unidos