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Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction.
Balanta-Melo, Julián; Torres-Quintana, María Angélica; Bemmann, Maximilian; Vega, Carolina; González, Constanza; Kupczik, Kornelius; Toro-Ibacache, Viviana; Buvinic, Sonja.
Afiliação
  • Balanta-Melo J; Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.
  • Torres-Quintana MA; School of Dentistry, Universidad del Valle, Cali, Colombia.
  • Bemmann M; Max Planck Weizmann Center for Integrative Archaeology and Anthropology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
  • Vega C; Department of Pathology and Oral Medicine, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.
  • González C; Max Planck Weizmann Center for Integrative Archaeology and Anthropology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
  • Kupczik K; Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.
  • Toro-Ibacache V; Biomedical Neuroscience Institute, Santiago, Chile.
  • Buvinic S; Max Planck Weizmann Center for Integrative Archaeology and Anthropology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
J Oral Rehabil ; 46(3): 233-241, 2019 Mar.
Article em En | MEDLINE | ID: mdl-30468522
BACKGROUND: Masseter muscle function influences mandibular bone homeostasis. As previously reported, bone resorption markers increased in the mouse mandibular condyle two days after masseter paralysis induced with botulinum toxin type A (BoNTA), followed by local bone loss. OBJECTIVE: This study aimed to evaluate the bone quality of both the mandibular condyle and alveolar process in the mandible of adult mice during the early stage of a BoNTA-induced masseter muscle atrophy, using a combined 3D histomorphometrics and shape analysis approach. METHODS: Adult BALB/c mice were divided into an untreated control group and an experimental group; the latter received one single BoNTA injection in the right masseter (BoNTA-right) and saline in the left masseter (Saline-left). 3D bone microstructural changes in the mandibular condyle and alveolar process were determined with high-resolution microtomography. Additionally, landmark-based geometric morphometrics was implemented to assess external shape changes. RESULTS: After 2 weeks, masseter mass was significantly reduced (P-value <0.001). When compared to Saline-left and untreated condyles, BoNTA-right condyles showed significant bone loss (P-value <0.001) and shape changes. No significant bone loss was observed in the alveolar processes of any of the groups (P-value >0.05). CONCLUSION: Condyle bone quality deteriorates at an early stage of BoNTA-induced masseter muscle atrophy, and before the alveolar process is affected. Since the observed bone microstructural changes resemble those in human temporomandibular joint degenerative disorders, the clinical safety of BoNTA intervention in the masticatory apparatus remains to be clarified.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Atrofia / Reabsorção Óssea / Toxinas Botulínicas Tipo A / Côndilo Mandibular / Músculo Masseter Limite: Animals Idioma: En Revista: J Oral Rehabil Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Atrofia / Reabsorção Óssea / Toxinas Botulínicas Tipo A / Côndilo Mandibular / Músculo Masseter Limite: Animals Idioma: En Revista: J Oral Rehabil Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido