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Chemical profile, liver protective effects and analgesic properties of a Solanum paniculatum leaf extract.
de Souza, Gabriela R; De-Oliveira, Ana Cecilia A X; Soares, Vitor; Chagas, Lucas F; Barbi, Nancy S; Paumgartten, Francisco José Roma; da Silva, Antonio Jorge R.
Afiliação
  • de Souza GR; Institute for Research on Natural Products, Federal University of Rio de Janeiro, RJ, 21941-902, Brazil.
  • De-Oliveira ACAX; Department of Biological Sciences, National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 21041210, Brazil.
  • Soares V; Institute for Research on Natural Products, Federal University of Rio de Janeiro, RJ, 21941-902, Brazil.
  • Chagas LF; Department of Biological Sciences, National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 21041210, Brazil.
  • Barbi NS; Department of Clinical and Toxicological Analyses, Faculty of Pharmacy, Federal University of Rio de Janeiro, RJ, 21941-902, Brazil.
  • Paumgartten FJR; Department of Biological Sciences, National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 21041210, Brazil. Electronic address: paum@ensp.fiocruz.br.
  • da Silva AJR; Institute for Research on Natural Products, Federal University of Rio de Janeiro, RJ, 21941-902, Brazil.
Biomed Pharmacother ; 110: 129-138, 2019 Feb.
Article em En | MEDLINE | ID: mdl-30466002
BACKGROUND/AIM: Solanum paniculatum L. (Solanaceae) is a plant native to South America where it is used in traditional medicine for different therapeutic indications. This study evaluated the chemical composition and the hepatoprotective and analgesic activities of S. paniculatum leaf extracts. MATERIAL AND METHODS: The chemical profile of an ethyl acetate partition (SPOE) of a S. paniculatum leaf infusion (SPAE) was analysed by high performance liquid chromatography coupled to high-resolution electrospray mass spectrometry (HPLC-ESIMS). Liver protective effects of SPAE (600 and 1200 mg/kg bw, po), or SPOE (300 mg/kg bw, po) were evaluated in a C57BL/6 mouse model of acetaminophen (AP, 600 mg/kg bw, ip) hepatotoxicity by measuring alanine (ALT) and aspartate (AST) aminotransferase activity in the serum, and reduced glutathione (GSH), and thiobarbituric acid reactive species (TBARs) levels in the hepatic tissue. RESULTS: HPLC-ESIMS analysis of the SPOE fraction tentatively identified 35 flavonoids, esters of hydroxycinnamic acid and isomers of chlorogenic acid. SPAE (600 and 1200 mg/kg bw) and SPOE (300 mg/kg bw) antagonized the rise in ALT and AST, and the depletion of GSH, and elevation of TBARs levels in the liver caused by AP. The liver protective effects of SPOE (300 mg/kg bw) against AP-induced liver toxicity mimicked those of N-acetyl-cysteine (NAC 300 or 600 mg/kg bw ip). The mouse writhing assay showed that SPOE (300 mg/kg bw po) has anti-nociceptive effects comparable to those of AP (180 mg/kg bw po). CONCLUSION: This study suggests that an extract of S. paniculatum leaves (SPOE), rich in phenolic compounds, is a promising herbal drug to prevent and treat AP poisoning and presents analgesic properties as well.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Folhas de Planta / Solanum / Doença Hepática Induzida por Substâncias e Drogas / Analgésicos Limite: Animals Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Folhas de Planta / Solanum / Doença Hepática Induzida por Substâncias e Drogas / Analgésicos Limite: Animals Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: França