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Reduced delta-band modulation underlies the loss of P300 responses in disorders of consciousness.
Rivera-Lillo, Gonzalo; Rojas-Líbano, Daniel; Burgos, Pablo; Egaña, Jose I; Chennu, Srivas; Maldonado, Pedro E.
Afiliação
  • Rivera-Lillo G; Physical Therapy Department, Faculty of Medicine, Universidad de Chile, Chile; Neuroscience Department, Faculty of Medicine, Universidad de Chile, Chile; Center of Integrated Studies in Neurorehabilitation, Clínica Los Coihues, Santiago, Chile.
  • Rojas-Líbano D; Laboratorio de Neurociencia Cognitiva y Social, Facultad de Psicología, Universidad Diego Portales, Santiago, Chile.
  • Burgos P; Physical Therapy Department, Faculty of Medicine, Universidad de Chile, Chile; Neuroscience Department, Faculty of Medicine, Universidad de Chile, Chile; Research and Development, Universidad Tecnológica de Chile, Inacap, Chile.
  • Egaña JI; Anesthesia Department, Faculty of Medicine, Universidad de Chile, Chile; Biomedical Neuroscience Institute, Universidad de Chile, Chile.
  • Chennu S; School of Computing, University of Kent, UK; Department of Clinical Neurosciences, University of Cambridge, UK.
  • Maldonado PE; Neuroscience Department, Faculty of Medicine, Universidad de Chile, Chile; Biomedical Neuroscience Institute, Universidad de Chile, Chile. Electronic address: pedro@uchile.cl.
Clin Neurophysiol ; 129(12): 2613-2622, 2018 12.
Article em En | MEDLINE | ID: mdl-30458356
OBJECTIVE: The P300 component of a sensory event-related potential is one of the major electrophysiological markers used to explore remnants of cognitive function in patients with disorders of consciousness (DoC). However, measuring the P300 in patients is complicated by significant inter-trial variability commonly observed in levels of arousal and awareness. To overcome this limitation, we analyzed single-trial modulation of power in the delta and theta frequency bands, which underlie the P300. METHODS: In a preliminary cross-sectional study using a 24-channel EEG and a passive own-name oddball paradigm, we analyzed event-related synchronization (ERS) across trials in the delta and theta bands in a sample of 10 control and 12 DoC subjects. RESULTS: In comparison to controls, DoC subjects presented a low percentage of trials where delta ERS was observed. In particular, coordinated modulation between delta and theta in response to the stimulus was absent, with a high percentage of trials where only theta ERS was observed. Further, we found a positive correlation between the percentage of epochs with delta ERS and the strength of the P300. CONCLUSIONS: Reduced modulation of spectral activity in the delta band in response to stimuli indicates a dissociation in the activity of the neural networks that oscillate in delta and theta ranges and contribute to the generation of the P300. SIGNIFICANCE: The reduction in spectral modulation observed in DoC provides a deeper understanding of neurophysiological dysfunction and the means to develop a more fine-grained marker of residual cognitive function in individual patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Vegetativo Persistente / Potenciais Evocados P300 / Ritmo Delta Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Neurophysiol Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Chile País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Vegetativo Persistente / Potenciais Evocados P300 / Ritmo Delta Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Neurophysiol Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Chile País de publicação: Holanda