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Fibroblast growth factor 21 in chronic kidney disease.
Suassuna, Paulo Giovanni de Albuquerque; de Paula, Rogério Baumgratz; Sanders-Pinheiro, Hélady; Moe, Orson W; Hu, Ming-Chang.
Afiliação
  • Suassuna PGA; Laboratory of Experimental Nephrology (LABNEX) and Interdisciplinary Nucleus of Laboratory Animal Studies (NIDEAL), Federal University of Juiz de Fora (UFJF), Rua José Lourenço Kelmer, S/n, Martelos, Juiz de Fora, MG, 36036-330, Brazil. paulosuassuna@gmail.com.
  • de Paula RB; Interdisciplinary Center for Studies, Research and Treatment in Nephrology (NIEPEN), Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil. paulosuassuna@gmail.com.
  • Sanders-Pinheiro H; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. paulosuassuna@gmail.com.
  • Moe OW; Laboratory of Experimental Nephrology (LABNEX) and Interdisciplinary Nucleus of Laboratory Animal Studies (NIDEAL), Federal University of Juiz de Fora (UFJF), Rua José Lourenço Kelmer, S/n, Martelos, Juiz de Fora, MG, 36036-330, Brazil.
  • Hu MC; Interdisciplinary Center for Studies, Research and Treatment in Nephrology (NIEPEN), Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
J Nephrol ; 32(3): 365-377, 2019 Jun.
Article em En | MEDLINE | ID: mdl-30430412
Fibroblast growth factor 21 (FGF21) is a member of the endocrine FGF family that acts as a metabolic regulator of both glucose and lipid metabolism. Similar to fibroblast growth factor 23 (FGF23), serum FGF21 levels rise progressively with the loss of renal function, reaching 20 times normal values in end-stage renal disease. In patients with chronic kidney disease (CKD), higher serum FGF21 levels correlate with poorer metabolic profile, higher inflammatory markers, more comorbidities, and higher mortality. The high serum FGF21 levels are above and beyond what can be explained by the loss of FGF21 renal clearance, suggesting increased production and/or impaired non-renal clearance. In diabetic nephropathy, serum FGF21 levels correlate with the severity of albuminuria and faster loss of glomerular filtrate rate and can potentially be a biomarker of poor prognostic. The observational and associative human data contrast sharply with in vitro and in vivo preclinical experimental data, which is more in line with a protective role of FGF21 in chronic nephropathies. We here review the physiology of FGF21, and the literature regarding its behavior in CKD with particular focus on diabetic nephropathy. Finally, we speculate on the role of FGF21 in CKD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Insuficiência Renal Crônica / Fatores de Crescimento de Fibroblastos / Rim Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Nephrol Assunto da revista: NEFROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Itália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Insuficiência Renal Crônica / Fatores de Crescimento de Fibroblastos / Rim Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Nephrol Assunto da revista: NEFROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Itália