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Porphyrins are increased in the faeces of patients with prostate cancer: a case-control study.
Gotardelo, Daniel Riani; Courrol, Lilia Coronato; Bellini, Maria Helena; de Oliveira Silva, Flávia Rodrigues; Soares, Carlos Roberto Jorge.
Afiliação
  • Gotardelo DR; Instituto de Pesquisas Energéticas e Nucleares, IPEN-CNEN/SP, Av. Prof. Lineu Prestes, 2242- Cidade Universitária, São Paulo, 05508-000, Brazil. danielriani@uol.com.br.
  • Courrol LC; Instituto Tocantinense Presidente Antônio Carlos - ITPAC Palmas, Tocantins, Brazil. danielriani@uol.com.br.
  • Bellini MH; Instituto de Ciências Ambientais Químicas e Farmacêuticas (ICAQF), Departamento de Física (DF), UNIFESP, Campus Diadema, São Paulo, Brazil.
  • de Oliveira Silva FR; Instituto de Pesquisas Energéticas e Nucleares, IPEN-CNEN/SP, Av. Prof. Lineu Prestes, 2242- Cidade Universitária, São Paulo, 05508-000, Brazil.
  • Soares CRJ; Instituto de Pesquisas Energéticas e Nucleares, IPEN-CNEN/SP, Av. Prof. Lineu Prestes, 2242- Cidade Universitária, São Paulo, 05508-000, Brazil.
BMC Cancer ; 18(1): 1090, 2018 Nov 12.
Article em En | MEDLINE | ID: mdl-30419859
BACKGROUND: Experimental models of prostate cancer have demonstrated increased levels of protoporphyrin IX (PpIX) in the blood and faeces of mice. Hence, the quantification of these autofluorescent molecules could be hypothesized to be a potential marker for this type of tumour. In this case-control study, the autofluorescence of porphyrins in human faeces from patients with prostate cancer and control subjects was analysed using fluorescence spectroscopy. METHODS: First, 3 mL of analytical-grade acetone was added to 0.3 g of faeces, and the mixture was macerated and centrifuged at 4000 rpm for 15 min. The supernatant was analysed spectroscopically. The emission spectra from 550 to 750 nm were obtained by exciting the samples at 405 nm. RESULTS: A significant difference between the samples from control and cancer subjects was established in the spectral region of 670-675 nm (p = 0.000127), which corresponds to a significant increase in faecal porphyrins in patients with cancer. There was no statistically significant correlation between PSA levels and faecal porphyrins. CONCLUSION: In this preliminary study conducted in humans, the results show a simple and non-invasive method to assess faecal porphyrins, which have the potential to function as a tumour biomarker in patients with prostate cancer. This approach has improved sensitivity and specificity over PSA testing. Additional prospective studies with larger sample sizes are required to validate these findings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Porfirinas / Neoplasias da Próstata / Fezes Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Aged / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Porfirinas / Neoplasias da Próstata / Fezes Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Aged / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido