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The Role of Co-Stimulatory Molecules in Chagas Disease.
Pinto, Bruna F; Medeiros, Nayara I; Fontes-Cal, Tereza C M; Naziazeno, Isabela M; Correa-Oliveira, Rodrigo; Dutra, Walderez O; Gomes, Juliana A S.
Afiliação
  • Pinto BF; Institute of Biological Sciences, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil. bruna_fernandes_6@hotmail.com.
  • Medeiros NI; René Rachou Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais 30.190-009, Brazil. naymedeiros@yahoo.com.
  • Fontes-Cal TCM; Institute of Biological Sciences, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil. t.t.cal@hotmail.com.
  • Naziazeno IM; Institute of Biological Sciences, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil. isabelamarques_s21995@hotmail.com.
  • Correa-Oliveira R; René Rachou Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais 30.190-009, Brazil. correa@minas.fiocruz.br.
  • Dutra WO; National Institute of Science and Technology in Tropical Diseases, INCT-DT, Belo Horizonte, Minas Gerais 31270-901, Brazil. correa@minas.fiocruz.br.
  • Gomes JAS; Institute of Biological Sciences, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil. wdutra@icb.ufmg.br.
Cells ; 7(11)2018 Nov 07.
Article em En | MEDLINE | ID: mdl-30405039
Chagas disease, caused by Trypanosoma cruzi, is a potentially life-threatening tropical disease endemic to Latin American countries that affects approximately 8 million people. In the chronic phase of the disease, individuals are classified as belonging to the indeterminate clinical form or to the cardiac and/or digestive forms when clinical symptoms are apparent. The relationship between monocytes and lymphocytes may be an important point to help clarify the complexity that surrounds the clinical symptoms of the chronic phase of Chagas disease. The co-stimulatory signals are essential to determining the magnitude of T cell response to the antigen. The signals are known to determine the regulation of subsequent adaptive immune response. However, little is known about the expression and function of these molecules in Chagas disease. Therefore, this review aims to discuss the possible role of main pathways of co-stimulatory molecule-receptor interactions in this pathology that could be crucial to understand the disease dynamics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cells Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cells Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça