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Multi-objective Parameter Auto-tuning for Tissue Image Segmentation Workflows.
Taveira, Luis F R; Kurc, Tahsin; Melo, Alba C M A; Kong, Jun; Bremer, Erich; Saltz, Joel H; Teodoro, George.
Afiliação
  • Taveira LFR; Department of Computer Science, University of Brasília, Brasília, Brazil.
  • Kurc T; Department of Biomedical Informatics, Stony Brook University, Stony Brook, NY, USA.
  • Melo ACMA; Scientific Data Group, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
  • Kong J; Department of Computer Science, University of Brasília, Brasília, Brazil.
  • Bremer E; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.
  • Saltz JH; Department of Biomedical Engineering, Emory - Georgia Institute of Technology, Atlanta, GA, USA.
  • Teodoro G; Department of Mathematics and Statistics, Georgia State University, Atlanta, GA, USA.
J Digit Imaging ; 32(3): 521-533, 2019 06.
Article em En | MEDLINE | ID: mdl-30402669
We propose a software platform that integrates methods and tools for multi-objective parameter auto-tuning in tissue image segmentation workflows. The goal of our work is to provide an approach for improving the accuracy of nucleus/cell segmentation pipelines by tuning their input parameters. The shape, size, and texture features of nuclei in tissue are important biomarkers for disease prognosis, and accurate computation of these features depends on accurate delineation of boundaries of nuclei. Input parameters in many nucleus segmentation workflows affect segmentation accuracy and have to be tuned for optimal performance. This is a time-consuming and computationally expensive process; automating this step facilitates more robust image segmentation workflows and enables more efficient application of image analysis in large image datasets. Our software platform adjusts the parameters of a nuclear segmentation algorithm to maximize the quality of image segmentation results while minimizing the execution time. It implements several optimization methods to search the parameter space efficiently. In addition, the methodology is developed to execute on high-performance computing systems to reduce the execution time of the parameter tuning phase. These capabilities are packaged in a Docker container for easy deployment and can be used through a friendly interface extension in 3D Slicer. Our results using three real-world image segmentation workflows demonstrate that the proposed solution is able to (1) search a small fraction (about 100 points) of the parameter space, which contains billions to trillions of points, and improve the quality of segmentation output by × 1.20, × 1.29, and × 1.29, on average; (2) decrease the execution time of a segmentation workflow by up to 11.79× while improving output quality; and (3) effectively use parallel systems to accelerate parameter tuning and segmentation phases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Processamento de Imagem Assistida por Computador / Núcleo Celular / Rastreamento de Células Limite: Humans Idioma: En Revista: J Digit Imaging Assunto da revista: DIAGNOSTICO POR IMAGEM / INFORMATICA MEDICA / RADIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Processamento de Imagem Assistida por Computador / Núcleo Celular / Rastreamento de Células Limite: Humans Idioma: En Revista: J Digit Imaging Assunto da revista: DIAGNOSTICO POR IMAGEM / INFORMATICA MEDICA / RADIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos