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Study of the Effects of L-tryptophane Nanoparticles on Motor Behavior in Alzheimer's Experimental Models.
Miri, Andressa L; Hosni, Andressa P; Gomes, Jossinelma C; Mainardes, Rubiana M; Khalil, Najeh M; Del J V Marcano, Rossana G; da S Pereira, Mário C; Kerppers, Ivo I.
Afiliação
  • Miri AL; Undergraduate Student at the Physiotherapy Course, Universidade Estadual do Centro-Oeste, Guarapuava, PR, Brazil.
  • Hosni AP; Undergraduate Student at the Physiotherapy Course, Universidade Estadual do Centro-Oeste, Guarapuava, PR, Brazil.
  • Gomes JC; Undergraduate Student at the Physiotherapy Course, Universidade Estadual do Centro-Oeste, Guarapuava, PR, Brazil.
  • Mainardes RM; Department of Pharmacy, Universidade Estadual do Centro-Oeste, Guarapuava, PR, Brazil.
  • Khalil NM; Department of Pharmacy, Universidade Estadual do Centro-Oeste, Guarapuava, PR, Brazil.
  • Del J V Marcano RG; Post-graduate Program in Pharmaceutical Sciences, Universidade Estadual do Centro-Oeste, Guarapuava, PR, Brazil.
  • da S Pereira MC; Department of Physiotherapy Course, Universidade Estadual do Centro-Oeste, PR, Brazil.
  • Kerppers II; Department of Physiotherapy Course, Universidade Estadual do Centro-Oeste, PR, Brazil.
CNS Neurol Disord Drug Targets ; 18(1): 44-51, 2019.
Article em En | MEDLINE | ID: mdl-30394223
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease characterized by the progressive and incapacitating decay of cognitive, neuropsychiatric, and behavioral manifestations. L-tryptophan is the precursor amino acid of serotonin, which is a neurotransmitter responsible for mood balance and the sense of well-being and can be administered in the form of nanoparticles. OBJECTIVE: This study analyzed the effectiveness of L-tryptophan nanoparticles and L-tryptophan on behavioral physiological alterations resulting from AD in animal models. METHODS: The sample consisted of 50 Rattus norvegicus rats, divided in 10 groups with 5 animals each: one negative control (NC), three positive control groups (C3, C7, and C21), three groups treated with L-tryptophan nanoparticles (T3N, T7N, and T21N) at the concentration of 1.5 mg, and three groups treated with L-tryptophan (T3L, T7L, and T21L) at the concentration of 1.5 mg. The rats underwent stereotactic surgery to induce AD through the injection of amyloid beta-amyloid peptide1-42 in the intracerebroventricular region. All rats were submitted to pre- and post-surgery and post-treatment motor behavior evaluation through the Later Water Maze (LWM) and elevated cross-labyrinth (ECL). Histological analysis was performed to verify the presence of senile plaques, and the statistical analysis used the unpaired T-test. RESULTS: Significant intergroup differences were observed in some of the evaluated parameters between treated and untreated groups. CONCLUSION: It was concluded that the treatment with L-tryptophan nanoparticles was beneficial to improve behavioral reactions in the Alzheimer's model.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triptofano / Comportamento Animal / Doença de Alzheimer Limite: Animals Idioma: En Revista: CNS Neurol Disord Drug Targets Assunto da revista: NEUROLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triptofano / Comportamento Animal / Doença de Alzheimer Limite: Animals Idioma: En Revista: CNS Neurol Disord Drug Targets Assunto da revista: NEUROLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos