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Protective effects of Bidens pilosa on hepatoxicity and nephrotoxicity induced by carbon tetrachloride in rats.
Pegoraro, Cristiane Martinez Ruiz; Nai, Gisele Alborghetti; Garcia, Leonardo Alves; Serra, Fernanda de Maria; Alves, Juliana Apolônio; Chagas, Pedro Henrique Nahas; Oliveira, Décio Gomes de; Zocoler, Marcos Alberto.
Afiliação
  • Pegoraro CMR; Department of Pharmacology, University of Western São Paulo (UNOESTE), Presidente Prudente, SP, Brazil.
  • Nai GA; Department of Pathology, University of Western São Paulo (UNOESTE), Presidente Prudente, SP, Brazil.
  • Garcia LA; Faculty of Medicine of Presidente Prudente (FAMEPP), University of Western São Paulo (UNOESTE), Presidente Prudente, SP, Brazil.
  • Serra FM; Faculty of Biomedicine, University of Western São Paulo (UNOESTE), Presidente Prudente, SP, Brazil.
  • Alves JA; Faculty of Medicine of Presidente Prudente (FAMEPP), University of Western São Paulo (UNOESTE), Presidente Prudente, SP, Brazil.
  • Chagas PHN; Faculty of Medicine of Presidente Prudente (FAMEPP), University of Western São Paulo (UNOESTE), Presidente Prudente, SP, Brazil.
  • Oliveira DG; Faculty of Pharmacy, University of Western São Paulo (UNOESTE), Presidente Prudente, SP, Brazil.
  • Zocoler MA; Faculty of Pharmacy, University of Western São Paulo (UNOESTE), Presidente Prudente, SP, Brazil.
Drug Chem Toxicol ; 44(1): 64-74, 2021 Jan.
Article em En | MEDLINE | ID: mdl-30394117
The aim of this study was to assess the protective effects of oral and topical treatment with Bidens pilosa (BP) against carbon tetrachloride (CCl4)- induced toxicity. Fifty-six rats were divided into seven groups: A: CCl4 only; B: CCl4+oral BP; C: CCl4 and topical BP; D: CCl4+oral and topical BP; E: oral BP only; F: negative control; and G: positive control (cyclophosphamide). The animals were treated for 10 weeks. Blood samples were collected for tests of hepatic and renal function, and fragments of the liver, spleen, pancreas, kidney, and intestine were collected for histopathological analyses. Cells from the femoral bone marrow were used for a micronucleus test and 'comet assay'. Statistically significant differences were observed in the levels of gamma-glutamyl transpeptidase (GGT), albumin, urea and creatinine, hepatic inflammation, renal tubular lesion, and inflammation of the intestinal mucosa between the BP-treated groups and untreated group. The median number of micronuclei in group A was 4.00, in group G was 9.00 and in the other groups was 0.00. Group A had the lowest number of cells with a score of 0 and the greatest number with scores of 3 and 4, similar to the results obtained from group G using the 'comet assay'. Thus, BP effectively protected against the toxic effects of CCl4 on the liver, kidney, and intestine and exerted an antimutagenic effect on rats exposed to CCl4.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Antimutagênicos / Bidens / Doença Hepática Induzida por Substâncias e Drogas / Rim / Nefropatias / Fígado / Anti-Inflamatórios Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Drug Chem Toxicol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Antimutagênicos / Bidens / Doença Hepática Induzida por Substâncias e Drogas / Rim / Nefropatias / Fígado / Anti-Inflamatórios Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Drug Chem Toxicol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos