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Phytochemical screening and in vitro antibacterial, antifungal, antioxidant and antitumor activities of the red propolis Alagoas.
Silva, F R G; Matias, T M S; Souza, L I O; Matos-Rocha, T J; Fonseca, S A; Mousinho, K C; Santos, A F.
Afiliação
  • Silva FRG; Centro Universitário Cesmac - CESMAC, Rua Cônego Machado, Farol, CEP 57051-160, Maceió, AL, Brasil.
  • Matias TMS; Centro Universitário Cesmac - CESMAC, Rua Cônego Machado, Farol, CEP 57051-160, Maceió, AL, Brasil.
  • Souza LIO; Centro Universitário Cesmac - CESMAC, Rua Cônego Machado, Farol, CEP 57051-160, Maceió, AL, Brasil.
  • Matos-Rocha TJ; Centro Universitário Cesmac - CESMAC, Rua Cônego Machado, Farol, CEP 57051-160, Maceió, AL, Brasil.
  • Fonseca SA; Universidade Estadual de Ciências da Saúde de Alagoas - UNCISAL, Av. Comendador Leão, Trapiche, CEP 57025-000, Maceió, AL, Brasil.
  • Mousinho KC; Centro Universitário Cesmac - CESMAC, Rua Cônego Machado, Farol, CEP 57051-160, Maceió, AL, Brasil.
  • Santos AF; Centro Universitário Cesmac - CESMAC, Rua Cônego Machado, Farol, CEP 57051-160, Maceió, AL, Brasil.
Braz J Biol ; 79(3): 452-459, 2019.
Article em En | MEDLINE | ID: mdl-30379200
The study aimed to evaluate the antimicrobial activity, antioxidant, toxicity and phytochemical screening of the Red Propolis Alagoas. Antimicrobial activity was evaluated by disk diffusion method. Determination of antioxidant activity was performed using the DPPH assay (1.1-diphenyl-2-picrylhydrazyl), FTC (ferric thiocyanate) and determination of phenolic compounds by Follin method. Toxicity was performed by the method of Artemia salina and cytotoxicity by MTT method. The phytochemical screening for the detection of allelochemicals was performed. The ethanol extract of propolis of Alagoas showed significant results for antimicrobial activity, and inhibitory activity for Staphylococcus aureus and Candida krusei. The antioxidant activity of the FTC method was 80% to 108.3% hydrogen peroxide kidnapping, the DPPH method showed an EC50 3.97 mg/mL, the content of total phenolic compounds was determined by calibration curve gallic acid, resulting from 0.0005 mg/100 g of gallic acid equivalent. The extract was non-toxic by A. salina method. The propolis extract showed high activity with a higher percentage than 75% inhibition of tumor cells OVCAR-8, SF-295 and HCT116. Chemical constituents were observed as flavonones, xanthones, flavonols, and Chalcones Auronas, Catechins and leucoanthocyanidins. It is concluded that the extract can be tested is considered a potential source of bioactive metabolites.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Antibacterianos / Antifúngicos / Antineoplásicos / Antioxidantes Tipo de estudo: Diagnostic_studies / Screening_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz J Biol Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Antibacterianos / Antifúngicos / Antineoplásicos / Antioxidantes Tipo de estudo: Diagnostic_studies / Screening_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz J Biol Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil