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LprG and PE_PGRS33 Mycobacterium tuberculosis virulence factors induce differential mitochondrial dynamics in macrophages.
Aguilar-López, Bruno A; Correa, Francisco; Moreno-Altamirano, María Maximina B; Espitia, Clara; Hernández-Longoria, Rocío; Oliva-Ramírez, Jacqueline; Padierna-Olivos, Juan; Sánchez-García, Francisco J.
Afiliação
  • Aguilar-López BA; Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
  • Correa F; Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico City, Mexico.
  • Moreno-Altamirano MMB; Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
  • Espitia C; Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Hernández-Longoria R; Laboratorios de Especialidades Inmunológicas S.A de C.V, Mexico City, Mexico.
  • Oliva-Ramírez J; Tecnológico de Monterrey-CEM, Estado de Mexico, Mexico.
  • Padierna-Olivos J; Laboratorios de Especialidades Inmunológicas S.A de C.V, Mexico City, Mexico.
  • Sánchez-García FJ; Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
Scand J Immunol ; 89(1): e12728, 2019 Jan.
Article em En | MEDLINE | ID: mdl-30375016
The interaction of a pathogen with its host cell takes place at different levels, including the bioenergetics adaptation of both the pathogen and the host cell in the course of an infection. In this regard, Mycobacterium tuberculosis infection of macrophages induces mitochondrial membrane potential (Δψm) changes and cytochrome c release, depending on the bacteria strain's virulence, and the mitochondrial dynamics is modified by pathogens, such as Listeria monocytogenes. Here, we investigated whether two M. tuberculosis virulence factors are able to induce distinguishable bioenergetics traits in human monocyte-derived macrophages (MDMs). Results showed that Rv1411c (LprG, p27) induced mitochondrial fission, lowered the cell respiratory rate and modified the kinetics of mitochondrial Ca2+ uptake in response to agonist stimulation. In contrast, Rv1818c (PE_PGRS33) induced mitochondrial fusion, but failed to induce any appreciable effect on cell respiratory rate or mitochondrial Ca2+ uptake. Overall, these results suggest that two different virulence factors from the same pathogen (M. tuberculosis) induce differential effects on mitochondrial dynamics, cell respiration and mitochondrial Ca2+ uptake in MDMs. The timing of differential mitochondrial activity could ultimately determine the outcome of host-pathogen interactions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Virulência / Interações Hospedeiro-Patógeno / Dinâmica Mitocondrial / Macrófagos / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Scand J Immunol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Virulência / Interações Hospedeiro-Patógeno / Dinâmica Mitocondrial / Macrófagos / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Scand J Immunol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido