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Soluble tumor necrosis factor receptors are associated with severity of kidney dysfunction in pediatric chronic kidney disease.
Moreira, Janaina Matos; da Silva, Albená Nunes; Marciano Vieira, Érica Leandro; Teixeira, Antônio Lúcio; Kummer, Arthur Melo; Simões E Silva, Ana Cristina.
Afiliação
  • Moreira JM; Interdisciplinary Laboratory of Medical Research (LIIM) of the Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • da Silva AN; Pediatric Nephrology Unit, Department of Pediatrics, Faculty of Medicine, UFMG, Belo Horizonte, Minas Gerais, Brazil.
  • Marciano Vieira ÉL; Exercise Immunology and Inflammation Laboratory (LABIIEX/CEDUFOP), Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
  • Teixeira AL; Interdisciplinary Laboratory of Medical Research (LIIM) of the Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Kummer AM; Interdisciplinary Laboratory of Medical Research (LIIM) of the Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Simões E Silva AC; Interdisciplinary Laboratory of Medical Research (LIIM) of the Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Pediatr Nephrol ; 34(2): 349-352, 2019 02.
Article em En | MEDLINE | ID: mdl-30374604
BACKGROUND: In adult chronic kidney disease (CKD) patients, there is a positive association between inflammation and progressive renal dysfunction. Higher levels of soluble receptors of tumor necrosis factor (sTNFR) have been related to worst prognosis of adult CKD patients. Therefore, the present study aimed to evaluate soluble TNF receptors in children and adolescents with CKD and to search for an association with clinical and laboratory features. METHODS: Demographic, clinical, anthropometric, and laboratory data were evaluated in 34 pediatric patients with CKD and in 34 healthy sex- and age-matched controls. Blood samples were collected in both groups to measure sTNFR by enzyme-linked immunosorbent assay. The modified Schwartz formula was used to estimate glomerular filtration rate (GFR). RESULTS: Pediatric patients with CKD had significantly higher plasma concentrations of soluble TNF receptors types 1 and 2 (sTNFR1 and sTNFR2) in comparison to sex- and age-matched healthy controls. Plasma levels of sTNFR1 and sTNFR2 increased progressively as renal function worsened, being inversely and significantly correlated with GFR (r = - 0.853 for sTNFR1 and GFR, r = - 0.729 for sTNFR2 and GFR). CONCLUSIONS: Children and adolescents with CKD exhibited higher plasma levels of sTNFR1 and sTNFR2 than healthy controls, which increased in relation to renal function deterioration. Plasma levels of sTNFR1 and sTNFR2 emerge as markers of progressive CKD in pediatric patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Índice de Gravidade de Doença / Receptores Tipo I de Fatores de Necrose Tumoral / Receptores Tipo II do Fator de Necrose Tumoral / Insuficiência Renal Crônica / Rim Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Pediatr Nephrol Assunto da revista: NEFROLOGIA / PEDIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Índice de Gravidade de Doença / Receptores Tipo I de Fatores de Necrose Tumoral / Receptores Tipo II do Fator de Necrose Tumoral / Insuficiência Renal Crônica / Rim Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Pediatr Nephrol Assunto da revista: NEFROLOGIA / PEDIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha